Dig Liver Dis. 2019;51(7):1030-1035.
Nonalcoholic fatty liver disease is associated with breast cancer in nonobese women.
제1저자 곽민선 · 교신저자 임정윤
소속 (8)
- Department of Internal Medicine, Healthcare Research Institute, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, Korea. Electronic address: kms39@snuh.org.
- Department of Internal Medicine, Healthcare Research Institute, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, Korea. Electronic address: yjy@snuh.org.
- Department of Radiology, Healthcare Research Institute, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, Korea. Electronic address: an_nie@naver.com.
- Department of Internal Medicine, Healthcare Research Institute, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, Korea. Electronic address: gohwom@snu.ac.kr.
- Department of Internal Medicine, Healthcare Research Institute, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, Korea. Electronic address: drmirinae@snuh.org.
- Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: messmd@chol.com.
- Department of Internal Medicine, Healthcare Research Institute, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, Korea. Electronic address: jooskim@snu.ac.kr.
- Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address: dynoh@snuh.org.
Abstract
BACKGROUND Growing evidence supports that nonalcoholic fatty liver disease (NAFLD) is associated with extrahepatic cancers. Nonalcoholic fatty liver disease (NAFLD) and breast cancer share similar risk factors, including obesity.
AIM The aim of this case-control study was to investigate the association between NAFLD and breast cancer.
METHODS Subjects who received health screening, including mammography and breast and hepatic ultrasonography simultaneously, were included. Subjects diagnosed with breast cancer were matched with controls. Conditional logistic regression analyses were performed.
RESULTS Among 270 breast cancer patients and 270 controls, 81 cancer patients (30.0%) and 54 controls (20.0%) had NAFLD (P = 0.008). NAFLD was significantly associated with breast cancer in multivariate analysis (P = 0.046). When the interaction between obesity (BMI < 25 kg/m2 vs. ≥25 kg/m2) and NAFLD in breast cancer patients was examined, a significant effect modification between obesity and NAFLD in breast cancer was noted (P = 0.021). The subgroup analysis showed that NAFLD was significantly associated with breast cancer in the nonobese subgroup (odds ratio 3.04, 95% confidence interval 1.37-4.32, P = 0.002) but not in the obese group (P = 0.163).
CONCLUSIONS NAFLD was significantly associated with breast cancer independent of traditional risk factors, and this association existed in the nonobese subgroup but not in the obese subgroup.
Copyright © 2019. Published by Elsevier Ltd.
Keywords
Breast cancerFatty liverHepatic steatosisObesity
그 밖의 정보
- 출판 형태
- Journal Article
- 저널
- Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver · eISSN 1878-3562
- 전자 출판
- 2019-01-09
- MeSH
- Adiposity* · Adult · Body Mass Index · Breast Neoplasms / diagnostic imaging / epidemiology · Case-Control Studies · Female · Humans · Liver / pathology · Logistic Models · Mammography · Middle Aged · Multivariate Analysis · Non-alcoholic Fatty Liver Disease / diagnostic imaging / epidemiology · Obesity · Republic of Korea / epidemiology · Risk Factors · Ultrasonography