J Alzheimers Dis. 2023;91(4):1515-1525.
Positive Results from the Fecal Immunochemical Test Can Be Related to Dementia: A Nationwide Population-Based Study in South Korea.
제1저자 전유경 · 교신저자 임종필, 한경도
소속 (7)
- Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea.
- Department of Internal Medicine, Division of Gastroenterology, Seoul National University Bundang Hospital, Seongnam, Korea.
- Department of Biomedicine & Health Sciences, College of Medicine, Catholic University of Korea, Seoul, Korea.
- Department of Internal Medicine, Division of Gastroenterology, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Korea.
- Department of Internal Medicine, Chung-ang University College of Medicine, Seoul, Korea.
- Department of Internal Medicine, Division of Gastroenterology, Seoul National University Hospital, Seoul, Korea.
- Department of Statistics and Actuarial Science, Soongsil University, Seoul, Korea.
Abstract
BACKGROUND The fecal immunochemical test (FIT) is widely used in screening for colorectal cancer (CRC), but FIT results can be positive for diseases other than CRC.
OBJECTIVE We investigated the association between positive results of FIT and the incidence of dementia using a nationwide database.
METHODS FIT-positive participants were collected from a database provided by the Korean National Health Insurance Service.
RESULTS The incidence of all kinds of dementia was higher in FIT-positive than FIT-negative subjects (p < 0.0001). FIT-positive participants had a higher risk of Alzheimer's disease (AD) (p < 0.0001) and vascular dementia (p = 0.0002), compared to participants with FIT negativity. The risk of all kinds of dementia or AD in FIT-positive participants was higher in younger (age < 65 years) than older participants (p < 0.0001 for all kinds of dementia; p = 0.0002 for AD).
CONCLUSION FIT positivity was correlated with an increased risk of dementia, especially in participants under 65 years of age. The study suggests that clinicians can consider dementia when FIT-positive participants fail to show any malignancies.
Keywords
Alzheimer’s diseasedementiaoccult bloodpopulation surveillancevascular dementia
그 밖의 정보
- 출판 형태
- Journal Article, Research Support, Non-U.S. Gov't
- 저널
- Journal of Alzheimer's disease : JAD · eISSN 1875-8908
- MeSH
- Humans · Aged · Colorectal Neoplasms* / diagnosis / epidemiology / pathology · Early Detection of Cancer / methods · Occult Blood · Republic of Korea · Dementia* · Feces