J Am Heart Assoc. 2015;4(8):e002046.
Korean Atrial Fibrillation (AF) Network: Genetic Variants for AF Do Not Predict Ablation Success.
제1저자 최의근, 박재형 · 교신저자 박희남
소속 (3)
- Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea (E.K.C.).
- Cardiovascular Genome Center, Yonsei University Health System, Seoul, Korea (J.H.P., J.Y.L., C.M.N., M.K.H., J.S.U., B.J., Y.G.K., M.H.L., H.N.P.).
- Cardiac Arrhythmia Service and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA (S.A.L., P.T.E.) Program in Medical and Population Genetics, The Broad Institute of Harvard and MIT, Cambridge, MA (S.A.L., P.T.E.).
Abstract
BACKGROUND Genomewide association studies have identified several loci associated with atrial fibrillation (AF) and have been reportedly associated with response to catheter ablation for AF in patients of European ancestry; however, associations between top susceptibility loci and AF recurrence after ablation have not been examined in Asian populations. We examined whether the top single nucleotide polymorphisms (SNPs) at chromosomes 4q25 (PITX2), 16q22 (ZFHX3), and 1q21 (KCNN3) were associated with AF in a Korean population and whether these SNPs were associated with clinical outcomes after catheter ablation for AF.
METHODS AND RESULTS We determined the association between 4 SNPs and AF in 1068 AF patients who underwent catheter ablation (74.6% male, aged 57.5±10.9 years, 67.9% paroxysmal AF) and 1068 age- and sex-matched controls. The SNPs at the PITX2 and ZFHX3 loci, but not the KCNN3 locus, were significantly associated with AF (PITX2/rs6843082_G: odds ratio 3.41, 95% CI 2.55 to 4.55, P=1.32×10(-16); PITX2/rs2200733_T: odds ratio 2.05, 95% CI 1.66 to 2.53, P=2.20×10(-11); ZFHX3/rs2106261_A: odds ratio 2.33, 95% CI 1.87 to 2.91, P=3.75×10(-14); KCNN3/rs13376333_T: odds ratio 1.74, 95% CI 0.93 to 3.25, P=0.085). Among those patients who underwent catheter ablation for AF, none of the top AF-associated SNPs were associated with long-term clinical recurrence of AF after catheter ablation.
CONCLUSIONS SNPs at the PITX2 and ZFHX3 loci were strongly associated with AF in Korean patients. In contrast to prior reports, none of the 4 top AF-susceptibility SNPs predicted clinical recurrence after catheter ablation.
© 2015 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.
Keywords
atrial fibrillationcatheter ablationgenetic polymorphismphenotyperecurrence
Figures
그림 출처: PubMed Central 공개 논문 (PMC4599462)
그 밖의 정보
- 출판 형태
- Journal Article, Observational Study, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
- 저널
- Journal of the American Heart Association · eISSN 2047-9980
- 전자 출판
- 2015-08-13
- MeSH
- Aged · Asian People / genetics · Atrial Fibrillation / diagnosis / ethnology / genetics / physiopathology / surgery · Case-Control Studies · Catheter Ablation* / adverse effects · Chi-Square Distribution · Female · Genetic Association Studies · Genetic Predisposition to Disease · Heart Conduction System / physiopathology / surgery · Homeodomain Proteins / genetics · Humans · Logistic Models · Male · Middle Aged · Multivariate Analysis · Odds Ratio · Phenotype · Polymorphism, Single Nucleotide* · Proportional Hazards Models · Recurrence · Republic of Korea · Risk Assessment · Risk Factors · Small-Conductance Calcium-Activated Potassium Channels / genetics · Time Factors · Transcription Factors / genetics · Treatment Outcome · Homeobox Protein PITX2
- Substances
- Homeodomain Proteins · Small-Conductance Calcium-Activated Potassium Channels · Transcription Factors · Homeobox Protein PITX2 · KCNN3 protein, human · ZFHX3 protein, human
- 연구비
- NHLBI NIH HHS R01 HL104156 · NHLBI NIH HHS U01 HL065962 · NHLBI NIH HHS K23 HL114724 · NHLBI NIH HHS K23HL114724 · NHLBI NIH HHS R01HL104156 · NHLBI NIH HHS K24 HL105780 · NHLBI NIH HHS R01HL092577 · NHLBI NIH HHS R01 HL092577 · NHLBI NIH HHS K24HL105780 · NHLBI NIH HHS U19 HL065962 · NHLBI NIH HHS HL065962
- 데이터
- ClinicalTrials.gov: NCT02138695
- 참고문헌
- 27편