J Korean Med Sci. 2022;37(8):e67.

Kinetics of Neutralizing Antibody Responses Against SARS-CoV-2 Delta Variant in Patients Infected at the Beginning of the Pandemic.

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제1저자 최평균, 김유리 · 교신저자 박완범, 조남혁

PMID 35226425 PMC8885454 DOI 10.3346/jkms.2022.37.e67 IF 3.2 감염내과

소속 (4)

Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, Korea.
Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, Korea. chonh@snu.ac.kr.
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. wbpark1@snu.ac.kr.

Abstract

We investigated the kinetics of the neutralizing antibody responses to the severe acute respiratory syndrome-coronavirus-2 delta variant over the course of 1 year in 16 patients infected at the beginning of the pandemic. In patients with severe disease, neutralizing responses to the delta variant were detectable, albeit at lower levels than responses to the wild type. Neutralizing responses to the delta variant were undetectable, however, in asymptomatic persons. This finding implies that the vaccination strategy for persons with past natural infection should depend on the severity of the previous infection.

Keywords

COVID-19Delta VariantFRNTSARS-CoV-2

Figures

**Fig. 1** Neutralizing antibody responses against SARS-CoV-2/wt and the SARS-CoV-2 B.1.671.2 (Delta) variant in serially collected samples from 12 symptomatic patients and four asymptomatic individuals. (A) FRNT₅₀ titers against SARS-CoV-2/wt in asymptomatic persons. (B) FRNT₅₀ titers against the delta variant in asymptomatic persons. (C) FRNT₅₀ titers against SARS-CoV-2/wt in individuals who had recovered from mild COVID-19. (D) FRNT₅₀ titers against the delta variant in individuals who had recovered from mild COVID-19. (E) FRNT₅₀ titers against SARS-CoV-2/wt in individuals who had recovered from severe COVID-19. (F) FRNT₅₀ titers against the delta variant in individuals who had recovered from severe COVID-19. Titers ≤ 10 were regarded as 10 and dotted lines indicate 1:40 titer. WT = wild type, FRNT = focus reduction neutralization test, SARS-CoV-2 = severe acute respiratory syndrome-coronavirus-2, COVID-19 = coronavirus disease 2019.

그림 출처: PubMed Central 공개 논문 (PMC8885454)

Conflict of interest statement

The authors have no potential conflicts of interest to disclose.

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