Cell Rep. 2021;36(4):109438.
IL-15 enhances CCR5-mediated migration of memory CD8+ T cells by upregulating CCR5 expression in the absence of TCR stimulation.
제1저자 서인호, 은혁수, 김자경, 신의철 · 교신저자 김원, 박수형, 신의철
소속 (7)
- Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.
- Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon 35015, Republic of Korea.
- Department of Internal Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin 16995, Republic of Korea.
- Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul 07061, Republic of Korea.
- Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul 07061, Republic of Korea. Electronic address: drwon1@snu.ac.kr.
- Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea. Electronic address: park3@kaist.ac.kr.
- Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea. Electronic address: ecshin@kaist.ac.kr.
Abstract
During microbial infection, bystander CD8+ T cells that are not specific to infecting pathogens can be activated by interleukin (IL)-15. However, the tissue-homing properties of bystander-activated CD8+ T cells have not been elucidated. Here, we examine the effects of IL-15 on the expression of chemokine receptors on CD8+ T cells and their migration. IL-15 upregulates CCR5 in memory CD8+ T cells in the absence of T cell receptor (TCR) stimulation and enhances CCR5-dependent migration. IL-15-induced CCR5 upregulation is abrogated by TCR stimulation, indicating that CCR5 is upregulated in bystander-activated CD8+ T cells. Moreover, CCR5 signals increase proliferation and cytotoxic protein expression in IL-15-treated memory CD8+ T cells, although the increase has a small extent. CCR5 upregulation in bystander-activated CD8+ T cells is associated with severe liver injury in patients with acute hepatitis A. Altogether, the results indicate that CCR5 upregulation by IL-15 mediates the migration of bystander-activated CD8+ T cells.
Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.
Keywords
CCR5IL-15bystander-activated CD8(+) T cellsmigration
Conflict of interest statement
Declaration of interests The authors declare no competing interests.
그 밖의 정보
- 출판 형태
- Journal Article, Research Support, Non-U.S. Gov't
- 저널
- Cell reports · eISSN 2211-1247
- MeSH
- Acute Disease · Adult · Animals · CD8-Positive T-Lymphocytes / metabolism · Cell Death / genetics · Cell Movement* · Cell Proliferation / genetics · Female · Hepatitis A / complications / genetics / immunology · Humans · Immunologic Memory* · Inflammation / complications / immunology / pathology · Interleukin-15 / metabolism · MAP Kinase Signaling System · Male · Mice, Inbred C57BL · Middle Aged · Receptors, Antigen, T-Cell / metabolism · Receptors, CCR5 / genetics / metabolism · Receptors, CCR7 / metabolism · Up-Regulation / genetics · Young Adult · Mice
- Substances
- CCR7 protein, human · Interleukin-15 · Receptors, Antigen, T-Cell · Receptors, CCR5 · Receptors, CCR7