In Vivo. 2021;35(4):2379-2390.
Identification of an Optimal Population for Allogeneic Hematopoietic Stem Cell Transplantation in Patients With Mature T and NK Cell Neoplasms.
제1저자 정은희 · 교신저자 변자민
소속 (4)
- Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
- Cancer Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.
- Center for Medical Innovation, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.
- Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea; jaminbyun@naver.com.
Abstract
BACKGROUND/AIM The prognosis of mature T and natural killer (NK) cell neoplasms still remains dismal, despite the advancements in the understanding of the heterogeneous features of these diseases. As allogeneic stem cell transplantation (alloSCT) is an attractive salvage option for relapsed/refractory patients, we conducted this study to identify those who might benefit the most from alloSCT.
PATIENTS AND METHODS This was a retrospective, single-center, longitudinal cohort study of patients who received alloSCT between December 2019 and January 2000.
RESULTS The median relapse-free survival and overall survival were 4.4 and 10.0 months, respectively. Disease control status at alloSCT and number of previous treatments were associated with survival outcomes. The conditioning intensity did not significantly alter survival.
CONCLUSION AlloSCT offers a cure chance for selected relapsed or refractory T and NK cell neoplasms, especially when used early and the disease is well controlled prior to transplantation.
Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
Keywords
Allogeneic hematopoietic stem cell transplantationT-cell lymphoma.lymphoma
Conflict of interest statement
The Authors have no conflicts of interest to disclose in relation to this study.
그 밖의 정보
- 출판 형태
- Journal Article
- 저널
- In vivo (Athens, Greece) · eISSN 1791-7549
- MeSH
- Graft vs Host Disease* · Hematopoietic Stem Cell Transplantation* · Humans · Killer Cells, Natural · Longitudinal Studies · Neoplasms* · Retrospective Studies · Stem Cell Transplantation · Transplantation Conditioning
- 참고문헌
- 24편