J Control Release. 2020;325:111-120.
Magnetically-driven implantable pump for on-demand bolus infusion of short-acting glucagon-like peptide-1 receptor agonist.
제1저자 이승호, 민세희, 조용찬, 한재훈 · 교신저자 조영민, 최영빈
소속 (8)
- Institute of Medical and Biological Engineering, Medical Research Center, Seoul National University, Seoul 03080, Republic of Korea.
- Department of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea; Department of Translational Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
- Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University, Seoul 08826, Republic of Korea.
- Department of Translational Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
- Department of Biomedical Engineering, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
- Department of Pathology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
- Department of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea; Department of Translational Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea. Electronic address: ymchomd@snu.ac.kr.
- Institute of Medical and Biological Engineering, Medical Research Center, Seoul National University, Seoul 03080, Republic of Korea; Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University, Seoul 08826, Republic of Korea; Department of Biomedical Engineering, Seoul National University College of Medicine, Seoul 03080, Republic of Korea. Electronic address: ybchoy@snu.ac.kr.
Abstract
For type 2 diabetic patients, short acting glucagon-like peptide-1 receptor agonist (GLP-1 RA) is often prescribed with frequent needled injections. Long-acting GLP-1 RA for less frequent injections do not mimic physiologic secretion of GLP-1. Therefore, an implantable pump is proposed in this work, which can deliver a short-acting GLP-1 RA, exenatide, without needles and batteries. The implanted pump can infuse an accurate amount of exenatide bolus only when a noninvasive magnetic force is applied from outside the body. The pump includes a safety feature of patterned magnets for actuation to prevent accidental infusion possibly caused by a general household magnet. The reservoir for exenatide is made of a flexible biomaterial and thus, a negative pressure build-up in the reservoir can be prevented even after multiple actuations and almost all drug consumption (~ 94%). This allows a reproducible drug dose for a longer period after implantation, hence less frequent replenishment procedures. The pump is also equipped with an intermediate container with two distinct check-valves and thus, the reservoir of exenatide can be further separated and better prevented from infiltration of the bodily fluid surrounding the implanted pump. When tested in Goto-Kakizaki rats, the pump demonstrates the efficacy of exenatide similar to conventional subcutaneous injections. Therefore, the pump can be promising for patient-friendly, optimal delivery of short-acting GLP-1 RA that better follows the physiologic secretion profile of GLP-1.
Copyright © 2020 Elsevier B.V. All rights reserved.
Keywords
ExenatideGlucagon-like peptide-1 receptor agonistImplantable pumpOn-demand drug deliveryType 2 diabetes
그 밖의 정보
- 출판 형태
- Journal Article, Research Support, Non-U.S. Gov't
- 저널
- Journal of controlled release : official journal of the Controlled Release Society · eISSN 1873-4995
- 전자 출판
- 2020-06-30
- MeSH
- Animals · Diabetes Mellitus, Type 2* · Exenatide / administration & dosage · Humans · Hypoglycemic Agents / administration & dosage · Rats · Glucagon-Like Peptide-1 Receptor Agonists*
- Substances
- Hypoglycemic Agents · Exenatide · Glucagon-Like Peptide-1 Receptor Agonists