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SCI 발표논문

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J Control Release. 2020;325:111-120.

Magnetically-driven implantable pump for on-demand bolus infusion of short-acting glucagon-like peptide-1 receptor agonist.

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제1저자 이승호, 민세희, 조용찬, 한재훈 · 교신저자 조영민, 최영빈

PMID 32619744 DOI 10.1016/j.jconrel.2020.06.022 IF 12.4 내분비대사내과
소속 (8)
  1. Institute of Medical and Biological Engineering, Medical Research Center, Seoul National University, Seoul 03080, Republic of Korea.
  2. Department of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea; Department of Translational Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
  3. Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University, Seoul 08826, Republic of Korea.
  4. Department of Translational Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
  5. Department of Biomedical Engineering, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
  6. Department of Pathology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
  7. Department of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea; Department of Translational Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea. Electronic address: ymchomd@snu.ac.kr.
  8. Institute of Medical and Biological Engineering, Medical Research Center, Seoul National University, Seoul 03080, Republic of Korea; Interdisciplinary Program in Bioengineering, College of Engineering, Seoul National University, Seoul 08826, Republic of Korea; Department of Biomedical Engineering, Seoul National University College of Medicine, Seoul 03080, Republic of Korea. Electronic address: ybchoy@snu.ac.kr.

Abstract

For type 2 diabetic patients, short acting glucagon-like peptide-1 receptor agonist (GLP-1 RA) is often prescribed with frequent needled injections. Long-acting GLP-1 RA for less frequent injections do not mimic physiologic secretion of GLP-1. Therefore, an implantable pump is proposed in this work, which can deliver a short-acting GLP-1 RA, exenatide, without needles and batteries. The implanted pump can infuse an accurate amount of exenatide bolus only when a noninvasive magnetic force is applied from outside the body. The pump includes a safety feature of patterned magnets for actuation to prevent accidental infusion possibly caused by a general household magnet. The reservoir for exenatide is made of a flexible biomaterial and thus, a negative pressure build-up in the reservoir can be prevented even after multiple actuations and almost all drug consumption (~ 94%). This allows a reproducible drug dose for a longer period after implantation, hence less frequent replenishment procedures. The pump is also equipped with an intermediate container with two distinct check-valves and thus, the reservoir of exenatide can be further separated and better prevented from infiltration of the bodily fluid surrounding the implanted pump. When tested in Goto-Kakizaki rats, the pump demonstrates the efficacy of exenatide similar to conventional subcutaneous injections. Therefore, the pump can be promising for patient-friendly, optimal delivery of short-acting GLP-1 RA that better follows the physiologic secretion profile of GLP-1.

Copyright © 2020 Elsevier B.V. All rights reserved.

Keywords

ExenatideGlucagon-like peptide-1 receptor agonistImplantable pumpOn-demand drug deliveryType 2 diabetes

그 밖의 정보
출판 형태
Journal Article, Research Support, Non-U.S. Gov't
저널
Journal of controlled release : official journal of the Controlled Release Society · eISSN 1873-4995
전자 출판
2020-06-30
MeSH
Animals · Diabetes Mellitus, Type 2* · Exenatide / administration & dosage · Humans · Hypoglycemic Agents / administration & dosage · Rats · Glucagon-Like Peptide-1 Receptor Agonists*
Substances
Hypoglycemic Agents · Exenatide · Glucagon-Like Peptide-1 Receptor Agonists