J Korean Med Sci. 2014;29 Suppl 2(Suppl 2):S117-22.

Analysis of correlation between 24-hour urinary sodium and the degree of blood pressure control in patients with chronic kidney disease and non-chronic kidney disease.

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제1저자 구호석 · 교신저자 진호준

PMID 25317015 PMC4194281 DOI 10.3346/jkms.2014.29.S2.S117 IF 3.2 신장내과

소속 (6)

Department of Internal Medicine, Seoul Paik Hospital, Inje University College of Medicine, Seoul, Korea. ; The Research Institute for Salt and Health, Seongnam, Korea.
The Research Institute for Salt and Health, Seongnam, Korea. ; Department of Internal Medicine, Armed Forces Capital Hospital, Seongnam, Korea.
Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea. ; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Department of Internal Medicine, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea.
The Research Institute for Salt and Health, Seongnam, Korea. ; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. ; Renal Institute, Seoul National University Medical Research Center, Seoul, Korea. ; Seoul K-Clinic, Seoul, Korea.
Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea. ; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. ; Renal Institute, Seoul National University Medical Research Center, Seoul, Korea. ; Seoul K-Clinic, Seoul, Korea. ; Department of Immunology, Seoul National University Postgraduate School, Seoul, Korea.

Abstract

We investigated the association between 24-hr urinary sodium (24UNA) and adequacy of blood pressure (BP) control in patients with chronic kidney disease (CKD) and nonCKD. All data were collected retrospectively by accessing the electrical medical records in patients with 24-hr urine collection and serum creatinine. Enrolled 400 subjects were subgrouped by the amount of 24UNA, or CKD stage. The appropriate BP was defined as BP < 130/80 mmHg for subjects with proteinuria, and BP < 140/90 mmHg for subjects without proteinuria. The mean level of 24UNA was 166±76 mEq/day. The 24UNA group was an independently related factor to diastolic BP as a continuous variable. The rate of appropriate BP control in patients with proteinuria was highest in 24UNA <100 mEq/L (P=0.012). The odds to fail achievement of BP target in subjects with 24UNA≥90 mEq/day was 2.441 (1.249-4.772, P=0.009) higher than that of 24UNA <90 mEq/day among participants with proteinuria. There was difference in the amount of 24UNA between CKD and non-CKD except each stage of CKD group. In conclusion, salt intake estimated by 24-hr urine sodium excretion is a risk factor to achieve appropriate BP control.

Keywords

Blood pressureHypertensionRenal insufficiencySalt

Figures

**Fig. 1** The estimated levels of blood pressures in 24UNA group adjusted with related factors (see Table 2) by ANCOVA test. ^*P value = 0.030 compared to group with 24 hr-urine sodium < 100 mEq/day. The bar means the 95% confidence interval of estimated value in each group.

**Fig. 2** Frequency of BP<130/80 mmHg or<140/90 mmHg among all participants according to levels of 24-hr urine sodium.

**Fig. 3** The prevalence of 24-hr urine sodium < 100 mEq in each group of chronic kidney disease (CKD). ^*P < 0.05 compared to Non-CKD group.

**Fig. 4** The estimated value of 24-hr urine sodium in CKD groups adjusted with related factors, such as history of cancer, DBP, BMI, glucose, uric acid, serum albumin stratified with 3.0 g/dL, and 24-hr urine protein, by ANCOVA test. The bar means the 95% confidence interval of estimated value in each group.

그림 출처: PubMed Central 공개 논문 (PMC4194281)

Conflict of interest statement

The authors declare that they have no conflicts of interest to disclose.

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