HPB (Oxford). 2026;28(3):324-332.
Role of endoscopic ultrasonography in differential diagnosis of gallbladder wall thickening: a multi-center retrospective study.
제1저자 이민우, 김성훈, 백우현 · 교신저자 조재희, 이상협
소속 (10)
- Department of Internal Medicine and Liver Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea; Department of Internal Medicine, Armed Forces Capital Hospital, Seongnam, South Korea.
- Division of Gastroenterology, Department of Internal Medicine, Jeonbuk National University Medical School, Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, South Korea.
- Department of Internal Medicine and Liver Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
- Division of Gastroenterology, Department of Internal Medicine, Hallym University Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Gyeonggi-do, South Korea.
- Department of Internal Medicine, Asan Medical Center, Seoul, South Korea.
- Department of Internal Medicine, Seoul Metropolitan Government Boramae Medical Center, Seoul National University College of Medicine, Seoul, South Korea.
- Division of Biliopancreas, Department of Internal Medicine, Wonkwang University Hospital, Iksan, South Korea.
- Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.
- Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea. Electronic address: jhcho9328@yuhs.ac.
- Department of Internal Medicine and Liver Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea. Electronic address: gidoctor@snu.ac.kr.
Abstract
BACKGROUND There are limited data on the usefulness of endoscopic ultrasonography (EUS) in determining malignancy in gallbladder wall thickening.
METHODS In this multicenter retrospective study, patients who underwent EUS for gallbladder wall thickening from 2011 to 2021 at seven tertiary hospitals were reviewed. The main outcome was the diagnostic performance of EUS in differentiating gallbladder tumors. Logistic regression analyses were performed to identify key EUS findings.
RESULTS We reviewed 309 patients who underwent EUS for gallbladder wall thickening and excluded 83 patients who did not undergo surgical resection. Among 226 patients who underwent cholecystectomy, 48 patients were diagnosed with gallbladder tumors and 176 patients were diagnosed with benign diseases. EUS showed a sensitivity of 79.31 % and a specificity of 92.86 % for diagnosing gallbladder tumors. Multivariate analysis revealed that wall thickness greater than 14 mm (P < 0.001) and disrupted layer (P < 0.001) were associated with gallbladder tumors. On the other hand, the presence of intramuscular cysts (P = 0.013) and comet tail sign (P = 0.004) were associated with benign diseases.
CONCLUSION EUS is a useful method for differential diagnosis of gallbladder wall thickening. Wall thickness greater than 14 mm and layer disruption are key findings of gallbladder tumors.
Copyright © 2025 International Hepato-Pancreato-Biliary Association Inc. Published by Elsevier Ltd. All rights reserved.
Conflict of interest statement
Conflicts of interest None to declare.
그 밖의 정보
- 출판 형태
- Journal Article, Multicenter Study
- 저널
- HPB : the official journal of the International Hepato Pancreato Biliary Association · eISSN 1477-2574
- 전자 출판
- 2025-12-03
- MeSH
- Humans · Retrospective Studies · Female · Male · Diagnosis, Differential · Endosonography* · Middle Aged · Gallbladder Neoplasms* / diagnostic imaging / pathology / surgery · Aged · Gallbladder* / diagnostic imaging / pathology · Adult · Predictive Value of Tests · Gallbladder Diseases* / diagnostic imaging / pathology · Aged, 80 and over