Cancer Lett. 2009;273(2):266-72.
Cathepsin B is a target of Hedgehog signaling in pancreatic cancer.
제1저자 황진혁 · 교신저자 김용태
소속 (1)
- Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, 28 Yungon-dong Chongno-gu, Seoul 110-744, Republic of Korea.
Abstract
This study investigated the influence of cathepsin B (CATB), a downstream target of Hedgehog (Hh) signaling, in pancreatic cancer. Cyclopamine (Hh signal inhibitor) suppressed expression of Shh, as well as Hh-induced transcription factor Gli1, and induced apoptosis in Shh-positive pancreatic cancer cell line (PANC-1). Microarray analysis revealed CATB as a gene downregulated by Hh. Cyclopamine reduced CATB protein and mRNA levels. Cyclopamine or CATB inhibitor reduced PANC-1 cell invasiveness (P<0.05). CATB expression in human pancreatic cancer tissues tended to correlate with Shh expression (P=0.053). Conclusively, Hh targets CATB and Hh signaling through CATB might influence pancreatic cancer cell invasiveness.
그 밖의 정보
- 출판 형태
- Journal Article, Research Support, Non-U.S. Gov't
- 저널
- Cancer letters · eISSN 1872-7980
- 전자 출판
- 2008-11-11
- MeSH
- Adult · Aged · Aged, 80 and over · Cathepsin B / metabolism · Cell Line, Tumor · Female · Gene Expression Regulation, Neoplastic* · Hedgehog Proteins / metabolism · Humans · Male · Middle Aged · Neoplasm Invasiveness · Pancreatic Neoplasms / metabolism · RNA, Messenger / metabolism · Signal Transduction
- Substances
- Hedgehog Proteins · RNA, Messenger · SHH protein, human · Cathepsin B