Int J STD AIDS. 2016;27(11):1013-5.
Immune reconstitution inflammatory syndrome versus non-immune reconstitution inflammatory syndrome lymphoma in HIV patients on antiretroviral therapy.
제1저자 최평균,박진용 · 교신저자 박완범
소속 (2)
- Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
- Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea wbpark1@snu.ac.kr.
Abstract
Little is known about differences between immune reconstitution inflammatory syndrome (IRIS) and non-IRIS lymphoma in HIV patients on antiretroviral therapy (ART). The aim of this study was to describe the characteristics of IRIS and non-IRIS lymphoma in Korean HIV-positive patients on ART compared with lymphoma in those off ART. Of 1490 patients, 41 (3%) had lymphoma. Of these, 27 cases (66%) were classified as lymphoma off ART, eight as IRIS lymphoma, and six as non-IRIS lymphoma on ART. Hodgkin lymphoma was significantly more common among patients with non-IRIS lymphoma on ART than among those with lymphoma off ART (P = 0.005), whereas there was no Hodgkin lymphoma among IRIS lymphoma. Stage IV lymphoma was significantly rarer in non-IRIS lymphoma on ART than in lymphoma off ART (P = 0.007). Non-IRIS lymphoma on ART tends to have a better survival rate than lymphoma off ART (Kaplan-Meier survival analysis, P = 0.167), while IRIS lymphoma exhibited a survival rate similar to lymphoma off ART (P = 0.618). In Korean HIV-positive patients, there were significantly more cases of Hodgkin lymphoma of a less advanced stage in non-IRIS lymphoma on ART than in lymphoma off ART, in contrast to IRIS lymphoma.
© The Author(s) 2016.
Keywords
AIDSHIVcancerimmune reconstitution inflammatory syndromelymphoma
그 밖의 정보
- 출판 형태
- Journal Article
- 저널
- International journal of STD & AIDS · eISSN 1758-1052
- 전자 출판
- 2016-01-28
- MeSH
- AIDS-Related Opportunistic Infections / ethnology / mortality · Adult · Anti-HIV Agents / therapeutic use · Antiretroviral Therapy, Highly Active* · Female · HIV Infections / complications / drug therapy / ethnology · Humans · Immune Reconstitution Inflammatory Syndrome / complications / ethnology / mortality · Incidence · Kaplan-Meier Estimate · Lymphoma, AIDS-Related / ethnology / mortality · Lymphoma, Non-Hodgkin / ethnology / mortality · Male · Republic of Korea / epidemiology · Severity of Illness Index · Survival Analysis · Viral Load
- Substances
- Anti-HIV Agents