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Emerg Infect Dis. 2020;26(10):2484-2487.

Antibody Responses to SARS-CoV-2 at 8 Weeks Postinfection in Asymptomatic Patients.

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제1저자 최평균, 강창경 · 교신저자 박완범, 김의석

PMID 32579877 PMC7510710 DOI 10.3201/eid2610.202211 IF 7.9 감염내과

Abstract

We compared levels of severe acute respiratory syndrome coronavirus 2 neutralizing antibodies in recovery plasma from 7 completely asymptomatic coronavirus disease patients with those in symptomatic patients in South Korea. We found that serologic diagnostic testing was positive for 71% (5/7) of completely asymptomatic patients, but neutralizing antibody response occurred in all 7 patients.

Keywords

2019 novel coronavirus diseaseCOVID-19SARSSARS-CoV-2asymptomaticcoronaviruscoronavirus diseaseneutralizing antibodyrespiratory infectionssevere acute respiratory syndrome coronavirus 2viruseszoonoses

Figures

Figure
Figure Antibody response against severe acute respiratory syndrome coronavirus 2 at 8 weeks postinfection among patients and controls in South Korea. A) Serologic diagnostic test (ELISA) results. OD ratio indicates the ratio of the extinction of the patient sample over the extinction of the calibrator. B) Neutralization assay results. For each patient type, an outlined symbol indicates a negative test result, gray symbol a borderline result, and black symbol a positive result, as tested according to manufacturer recommendation. Bars represent mean values and SE. From each patient group other than the completely asymptomatic group, 3–4 patients were randomly selected for neutralization assay. The controls included 1 healthy volunteer and 2 patients with MERS. Ab, antibody; MERS, Middle East respiratory syndrome; OD, optical density.

그림 출처: PubMed Central 공개 논문 (PMC7510710)

그 밖의 정보
출판 형태
Letter, Research Support, Non-U.S. Gov't
저널
Emerging infectious diseases · eISSN 1080-6059
전자 출판
2020-06-24
MeSH
Antibodies, Neutralizing / blood · Antibodies, Viral / blood · Asymptomatic Infections · Betacoronavirus / immunology · COVID-19 · Coronavirus Infections / blood / diagnosis · Humans · Immunoglobulin G / blood · Pandemics · Plasma / immunology · Pneumonia, Viral / blood / diagnosis · Republic of Korea · SARS-CoV-2 · Serologic Tests · Time Factors
Substances
Antibodies, Neutralizing · Antibodies, Viral · Immunoglobulin G
참고문헌
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