Anticancer Res. 2006;26(5A):3429-38.
Antitumor activity of SK-7041, a novel histone deacetylase inhibitor, in human lung and breast cancer cells.
제1저자 이근욱 · 교신저자 방영주
소속 (1)
- Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Abstract
BACKGROUND A class of synthetic histone deacetylase (HDAC) inhibitors, which are hybrids of trichostatin A and MS-275 were previously developed. In this study, the antitumor effects of SK-7041, one of those novel HDAC inhibitors, was evaluated on lung and breast cancer cell lines.
MATERIALS AND METHODS Human lung and breast cancer cells, as well as normal human bronchial epithelial (NHBE) cells were treated with SK-7041, and results were compared with those of cells treated with suberoylanilide hydroxamic acid (SAHA).
RESULTS SK-7041 induced time-dependent histone hyperacetylation and showed more potent cytotoxicity than SAHA in cancer cells. These antiproliferative effects of SK-7041 were due to apoptotic cell death caused by G2/M-phase arrest and to a lesser extent to G1 arrest. Moreover, SK-7041 inhibited cancer cell proliferation more selectively than NHBE cell proliferation.
CONCLUSIONS These results suggest that SK-7041 may have potential anticancer activity.
그 밖의 정보
- 출판 형태
- Journal Article, Research Support, Non-U.S. Gov't
- 저널
- Anticancer research · ISSN 0250-7005
- MeSH
- Acetylation · Amides / toxicity · Annexin A5 / metabolism · Antineoplastic Agents / toxicity · Apoptosis / drug effects · Biphenyl Compounds / toxicity · Breast Neoplasms / metabolism / pathology · Cell Cycle / drug effects · Cell Line, Tumor · Cell Proliferation / drug effects · Enzyme Inhibitors / toxicity · Histone Deacetylase Inhibitors* · Humans · Hydroxamic Acids / toxicity · Immunoblotting · Lung Neoplasms / metabolism / pathology · Tumor Cells, Cultured · Vorinostat
- Substances
- Amides · Annexin A5 · Antineoplastic Agents · Biphenyl Compounds · Enzyme Inhibitors · Histone Deacetylase Inhibitors · Hydroxamic Acids · SK-7041 · Vorinostat