World J Gastroenterol. 2019;25(42):6354-6364.

Risk of inflammatory bowel disease in patients with chronic obstructive pulmonary disease: A nationwide, population-based study.

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제1저자 이주영 · 교신저자 임종필

PMID 31754295 PMC6861849 DOI 10.3748/wjg.v25.i42.6354 IF 7.7 소화기내과

소속 (6)

Department of Internal Medicine and Healthcare Research Institute, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul 06236, South Korea.
Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul 03080, South Korea. jpim0911@snu.ac.kr.
Department of Biostatics, College of Medicine, Catholic University of Korea, Seoul 06591, South Korea.
Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul 03080, South Korea.
Department of Internal Medicine, CHA Gangnam Medical Center, CHA University, Seoul 06135, South Korea.
Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 06273, South Korea.

Abstract

BACKGROUND There is a growing evidence regarding an increased risk of inflammatory bowel disease (IBD) among patients with airway diseases.

AIM To investigate the influence of chronic obstructive pulmonary disease (COPD) on the risk of IBD.

METHODS A nationwide, population-based study was conducted using data from the National Health Insurance Service database. A total of 1303021 patients with COPD and 6515105 non-COPD controls were identified. The COPD group was divided into the severe and the mild COPD group according to diagnostic criteria. The risk of IBD in patients with COPD compared to controls was analyzed by Cox proportional hazard regression models. The cumulative incidences of IBD were compared between the groups.

RESULTS The COPD group had higher incidences of IBD compared to non-COPD controls (incidence rate, 9.98 vs 7.18 per 100000 person-years, P < 0.001). The risk of IBD in the COPD group was increased by 1.38 (adjusted hazard ratio (HR); 95%CI: 1.25-1.52). The incidence rate of IBD was higher in the severe COPD group than in the mild COPD group (12.39 vs 9.77 per 100000 person-year, P < 0.001). The severity of COPD was associated with an increased risk of IBD (adjusted HR 1.70 in severe COPD, 95%CI: 1.27-2.21 and adjusted HR 1.35 in mild COPD, 95%CI: 1.22-1.49).

CONCLUSION The incidences of IBD were significantly increased in COPD patients in South Korea and the risk of developing IBD also increased as the severity of COPD increased.

Keywords

Chronic obstructive pulmonary diseaseClaim dataCrohn’s diseaseInflammatory bowel diseaseUlcerative colitis

Figures

**Figure 1** The cumulative incidence of inflammatory bowel disease in chronic obstructive pulmonary disease group and non-chronic obstructive pulmonary disease controls. IBD: Inflammatory bowel disease; COPD: Chronic obstructive pulmonary disease.

**Figure 2** Comparison of cumulative incidence of inflammatory bowel disease in patients with chronic obstructive pulmonary disease according to the severity of chronic obstructive pulmonary disease. IBD: Inflammatory bowel disease; COPD: Chronic obstructive pulmonary disease.

그림 출처: PubMed Central 공개 논문 (PMC6861849)

Conflict of interest statement

Conflict-of-interest statement: All authors declare no conflicts-of-interest related to this article.

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