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J Korean Med Sci. 2010;25(5):781-4.

Hematopoietic stem cell transplantation after posttransplant lymphoproliferative disorder.

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제1저자 김민주 · 교신저자 김인호

PMID 20436718 PMC2858841 DOI 10.3346/jkms.2010.25.5.781 IF 3.2 혈액종양내과
소속 (1)
  1. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.

Abstract

A 16-yr-old girl received liver transplantation for fulminant hepatitis. Aplastic anemia developed, and she received hematopoietic stem cell transplantation (HSCT). Eleven months after liver transplantation, abdominal lymph node enlargement and colon ulcers were observed, and colon biopsy showed posttransplant lymphoproliferative disorder (PTLD). Immunosuppression reduction was attempted, but it produced no therapeutic effect. Fourteen months after liver transplantation, she received a second HSCT due to engraftment failure, and PTLD resolved completely. The second HSCT can serve as cellular therapy for PTLD.

Keywords

Liver TransplantationPosttransplant Lymphoproliferative Disorder, Hematopoietic Stem Cell Transplantation

Figures

Fig. 1
Fig. 1 Abdomen CT 11 months after liver transplantation. Multiple conglomerated lymphadenopathies in the mesentery and para-aortic areas (arrow) were newly appeared.
Fig. 2
Fig. 2 Sigmoidoscopy on day 55 after the first HSCT. Multiple aphthoid ulcers (arrow) were shown.
Fig. 3
Fig. 3 Colon biopsy. H&E stain, original magnification.
Fig. 4
Fig. 4 Colon biopsy. EBV in situ hybridization of the colon biopsy specimen.
Fig. 5
Fig. 5 Abdomen CT 1 month after a second HSCT. Multiple conglomerated lymphadenopathies disappeared.
Fig. 6
Fig. 6 Sigmoidoscopy 1 month after a second HSCT. Multiple aphthoid ulcers disappeared.

그림 출처: PubMed Central 공개 논문 (PMC2858841)

그 밖의 정보
출판 형태
Case Reports, Journal Article
저널
Journal of Korean medical science · eISSN 1598-6357
전자 출판
2010-04-16
MeSH
Adolescent · Female · Hematopoietic Stem Cell Transplantation / methods · Humans · Liver Transplantation / adverse effects · Lymphoproliferative Disorders / etiology / surgery · Treatment Outcome
참고문헌
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