Front Cardiovasc Med. 2022;9:910225.

Type and Severity of Migraine Determines Risk of Atrial Fibrillation in Women.

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제1저자 이태민 · 교신저자 최의근

PMID 35711356 PMC9197451 DOI 10.3389/fcvm.2022.910225 IF 3 순환기내과

소속 (5)

Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea.
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.
Department of Statistics and Actuarial Science, Soongsil University, Seoul, South Korea.
Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Chest and Heart Hospital, Liverpool, United Kingdom.
Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.

Abstract

OBJECTIVE To evaluate sex differences in the risk of atrial fibrillation (AF) according to the type and severity of migraine.

METHODS We analyzed the nationwide health screening recipients in 2009 without previous AF diagnosis from the Korean National Health Insurance Service data. The diagnosis, type, and severity of migraine were determined using claims data. Newly developed AF was identified during a 10-year follow-up. Sex-difference in the effect of migraine on AF was evaluated.

RESULTS A total of 4,020,488 subjects were enrolled from January 1, to December 31, 2009 and followed-up through December 31, 2018; 4,986 subjects had migraine with aura (age 50.6 ± 14.0 years, men 29.3%); and 105,029 had migraine without aura (age 51.6 ± 14.3 years, men 30.9%). Risk of AF in a mild degree of migraine was similar to that in the control group, regardless of sex or the presence of aura. Severe migraine without aura modestly but significantly increased the risk of AF in both men and women compared to controls, with increase in AF risk being most prominent in women who had severe migraine with aura [incidence rate (IR) = 3.39, hazard ratio (HR)_adjust = 1.48, 95% confidence intervals (CI) = 1.18-1.85]. No significant association according to aura was observed in men with severe migraines (p for interaction 0.011).

CONCLUSION Severe migraine with aura significantly increased the risk of incident AF in women, but not in men. Surveillance for incident AF and prompt lifestyle modification may be beneficial, particularly for young women suffering from severe migraine with aura.

Keywords

atrial fibrillationgender differencesmigrainemigraine with aurawomen

Figures

**FIGURE 1** Study flow. Flow of establishment of the study population is shown. AF, atrial fibrillation.

**FIGURE 2** Sex-stratified cumulative incidence of atrial fibrillation in migraine patients. Cumulative hazard curves for AF according to the type of migraine in **(A)** men and **(B)** women.

**FIGURE 3** Sex-stratified comparison of risk of atrial fibrillation according to type and severity of migraine. The incidence rate of and multivariate adjusted *HRs* with 95% *CIs* for AF according to the type and severity of migraine are presented stratified by men and women. CI, confidence interval; HR, hazard ratio; p-y, person-year; otherwise, as shown in Figure 1.

그림 출처: PubMed Central 공개 논문 (PMC9197451)

Conflict of interest statement

E-KC Research grants or speaking fees from Bayer, BMS/Pfizer, Biosense Webster, Chong Kun Dang, Daiichi-Sankyo, Dreamtech Co., Ltd., Medtronic, Samjinpharm, Sanofi-Aventis, Seers Technology, and Skylabs. GL Consultant and speaker for BMS/Pfizer, Boehringer Ingelheim, and Daiichi-Sankyo. No fees were received personally. No other relationships or activities that could appear to have influenced the submitted work. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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