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J Neurogastroenterol Motil. 2018;24(4):528-535.

Aloe vera Is Effective and Safe in Short-term Treatment of Irritable Bowel Syndrome: A Systematic Review and Meta-analysis.

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제1저자 홍승욱 · 교신저자 천재영

PMID 30153721 PMC6175553 DOI 10.5056/jnm18077 IF 3.7 소화기내과
소속 (2)
  1. Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea.
  2. Department of Food and Nutrition, Hoseo University, Asan, Chungcheongnam-do, Korea.

Abstract

BACKGROUND/AIMS To evaluate the efficacy and safety of Aloe vera (AV) in patients with irritable bowel syndrome (IBS).

METHODS We searched the MEDLINE, EMBASE, and Cochrane databases for studies dated between 1st January 1960 and 30th December 2017. Eligible randomized controlled trials (RCTs) compared AV to placebo in patients with IBS. The primary outcome was standardized mean difference of the change in severity of IBS symptoms as measured by patient-rated scales. Secondary outcomes included response rate of IBS symptoms and adverse events. Heterogeneity among studies was assessed using Cochrane's Q and I2 statistics.

RESULTS Three RCTs with a total of 151 patients with IBS were included. The meta-analysis showed a significant difference for patients with AV compared to those with placebo regarding improvement in IBS symptom score (standardized mean difference, 0.41; 95% CI, 0.07-0.75; P = 0.020). Using intention-to-treat analysis, the AV patients showed significantly better response rates of IBS symptoms compared to placebo (pooled risk ratio, 1.69; 95% CI, 1.05-2.73; P = 0.030). No adverse events related with AV were found in included studies. There was no significant heterogeneity of effects across studies (P = 0.900; I2 = 0%).

CONCLUSION AV is effective and safe for the treatment of patients with IBS compared to placebo.

Keywords

AloeIrritable bowel syndromeMeta-analysisReview

Figures

Figure 1
Figure 1 Flow chart of the study selection.
Figure 2
Figure 2 Evaluation of risk of bias. Green for low risk of bias, yellow for unclear risk of bias and red for high risk of bias. This figure indicates the risk of bias of each domain in each study.
Figure 3
Figure 3 Standardized mean differences in improvement of irritable bowel syndrome symptom scores. Comparison of mean differences in improvement of irritable bowel syndrome scores between Aloe vera and placebo groups, (A) the forest plots for all included studies, (B) high quality studies, and (C) subgroup analysis according to the treatment period: short-term (1 month) vs long-term (over 3 months) period. IV, inverse variance.
Figure 4
Figure 4 Response rates. Comparison of response rates between Aloe vera and placebo groups using (A) per-protocol and (B) intention-to-treat analysis. M-H, Mantel-Haenszel.

그림 출처: PubMed Central 공개 논문 (PMC6175553)

Conflict of interest statement

Conflicts of interest: None.

그 밖의 정보
출판 형태
Journal Article, Review
저널
Journal of neurogastroenterology and motility · ISSN 2093-0879
참고문헌
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