Cancer Lett. 2006;237(1):143-54.
SK-7041, a new histone deacetylase inhibitor, induces G2-M cell cycle arrest and apoptosis in pancreatic cancer cell lines.
제1저자 류지곤 · 교신저자 김용태
소속 (1)
- Departments of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, 28 Yungun-dong, Chongno-gu, Seoul 110-744, South Korea.
Abstract
A novel hybrid synthetic histone deacetylase inhibitor, SK-7041, was synthesized from hydroaxamic acid of trichostatin A (TSA) and pyridyl ring of MS-275. TSA and SK-7041 both induced apoptosis and G2-M cell cycle arrest in pancreatic cancer cell lines. The expressions of p21 and cyclin D2 were up-regulated and that of cyclin B1 was down-regulated by TSA or SK-7041. The expression levels of Mcl-1 and Bcl-XL but not those of Bcl-2, Bax, and Bak were suppressed by TSA or SK-7041 treatment. SK-7041 or TSA induced apoptosis and G2-M cell cycle arrest by up-regulating p21 and down-regulating cyclin B1, Mcl-1, and Bcl-XL.
그 밖의 정보
- 출판 형태
- Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
- 저널
- Cancer letters · ISSN 0304-3835
- 전자 출판
- 2005-07-11
- MeSH
- Amides / pharmacology · Antineoplastic Agents / pharmacology · Apoptosis* · Biphenyl Compounds / pharmacology · Cell Division · Cell Line, Tumor / drug effects · Cell Proliferation / drug effects · Cyclin B / metabolism · Cyclin B1 · Cyclin D2 · Cyclin-Dependent Kinase Inhibitor p21 / metabolism · Cyclins / metabolism · Dose-Response Relationship, Drug · Enzyme Inhibitors / pharmacology · G2 Phase · Histone Deacetylase Inhibitors* · Histone Deacetylases / metabolism · Histones / metabolism · Humans · Hydroxamic Acids / pharmacology · Myeloid Cell Leukemia Sequence 1 Protein · Neoplasm Proteins / metabolism · Pancreatic Neoplasms / enzymology / pathology · Proto-Oncogene Proteins c-bcl-2 / metabolism · bcl-X Protein / metabolism
- Substances
- Amides · Antineoplastic Agents · BCL2L1 protein, human · Biphenyl Compounds · CCNB1 protein, human · CCND2 protein, human · CDKN1A protein, human · Cyclin B · Cyclin B1 · Cyclin D2 · Cyclin-Dependent Kinase Inhibitor p21 · Cyclins · Enzyme Inhibitors · Histone Deacetylase Inhibitors · Histones · Hydroxamic Acids · Myeloid Cell Leukemia Sequence 1 Protein · Neoplasm Proteins · Proto-Oncogene Proteins c-bcl-2 · SK-7041 · bcl-X Protein · trichostatin A · Histone Deacetylases