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J Clin Hypertens (Greenwich). 2020;22(9):1659-1665.

Prediction of cardiovascular events using brachial-ankle pulse wave velocity in hypertensive patients.

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제1저자 김학령 · 교신저자 김학령

소속 (1)
  1. Division of Cardiology, Department of Internal Medicine, Boramae Medical Center, Seoul National University College of Medicine, Seoul, South Korea.

Abstract

The prognostic value of arterial stiffness in Korean hypertensive patients has not been specified. This study was performed to evaluate the prognostic value of brachial-ankle pulse wave velocity (baPWV) in Korean hypertensive patients and to propose a cutoff value of baPWV predicting future cardiovascular events. A total of 2561 hypertensive patients without documented cardiovascular disease (mean age, 63 years; 47% females) who underwent baPWV measurement were retrospectively analyzed. Composite events of cardiac death, non-fatal myocardial infarction, coronary revascularization, and ischemic stroke were assessed during the clinical follow-up period. During a median follow-up period of 4.14 years (interquartile range, 2.18-5.48 years), there were 69 cases of composite events (2.7%). In receiver operating characteristic curve analysis, the best cutoff value of baPWV predicting composite events was 1630 cm/s (sensitivity, 79.7%; specificity, 49.1%; area under curve, 0.674; 95% confidence interval [CI], 0.613-0.735; P < .001). In multivariable Cox regression analysis, higher baPWV (≥1630 cm/s) was independently associated with higher risk of the occurrence of composite events even after controlling for potential confounders (hazard ratio, 2.83; 95% confidence interval, 1.49-5.36; P = .001). In conclusion, increased baPWV in Korean hypertensive patients was associated with an increased risk of future cardiovascular events. In addition, we suggested 1630 cm as a cutoff value of baPWV for predicting cardiovascular events, which will be helpful in guiding the treatment strategy of Korean hypertensive patients.

©2020 Wiley Periodicals LLC.

Keywords

arterial stiffnessbrachial-ankle pulse wave velocitycutoff valuehypertensionprognosis

Conflict of interest statement

The authors declare there is no conflict of interest associated with this manuscript.

그 밖의 정보
출판 형태
Journal Article
저널
Journal of clinical hypertension (Greenwich, Conn.) · eISSN 1751-7176
전자 출판
2020-08-10
MeSH
Ankle Brachial Index · Female · Humans · Hypertension* / diagnosis / epidemiology · Male · Middle Aged · Pulse Wave Analysis · Retrospective Studies · Risk Factors · Vascular Stiffness
참고문헌
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