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Emerg Infect Dis. 2015;21(12):2186-9.

Kinetics of Serologic Responses to MERS Coronavirus Infection in Humans, South Korea.

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제1저자 박완범 · 교신저자 오명돈

PMID 26583829 PMC4672454 DOI 10.3201/eid2112.151421 IF 7.9 감염내과

Abstract

We investigated the kinetics of serologic responses to Middle East respiratory syndrome coronavirus (MERS-CoV) infection by using virus neutralization and MERS-CoV S1 IgG ELISA tests. In most patients, robust antibody responses developed by the third week of illness. Delayed antibody responses with the neutralization test were associated with more severe disease.

Keywords

MERSMERS-CoVMiddle East respiratory syndromeMiddle East respiratory syndrome coronavirusSouth Koreaantibodyclinical correlatescoronavirusdiagnosticshumansimmunitykineticsseroepidemiologic dataserologic responsesseverityviruses

Figures

Figure
Figure Antibody response kinetics in patients with Middle East respiratory syndrome coronavirus (MERS-CoV) infection, by days after illness onset, as determined by using a 50% endpoint plaque reduction neutralization test (PRNT50) (A) and an S1 IgG ELISA (B). Key indicates individual patients; Red indicates patients with severe illness requiring mechanical ventilation; blue indicates patients with severe illness requiring only supplemental oxygen therapy; and green indicates patients with mild illness. For better presentation, the PRNT50 titers have been jittered vertically (random noise added to prevent overplotting) (7) by adding random numbers to the titers within the range of −0.2 to 0.2 at the log scale. OD, optical density.

그림 출처: PubMed Central 공개 논문 (PMC4672454)

그 밖의 정보
출판 형태
Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
저널
Emerging infectious diseases · eISSN 1080-6059
MeSH
Animals · Antibodies, Viral / immunology · Antibody Affinity · Antibody Formation / immunology · Camelus / immunology · Coronavirus Infections / epidemiology / immunology / pathology · Female · Humans / blood / virology · Kinetics · Male · Middle East Respiratory Syndrome Coronavirus / immunology / pathogenicity · Republic of Korea / epidemiology
Substances
Antibodies, Viral
연구비
NIAID NIH HHS HHSN272201400006C
참고문헌
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