Am J Surg. 2015;209(4):709-16.
Lower maximum standardized uptake value of fluorine-18 fluorodeoxyglucose positron emission tomography coupled with computed tomography imaging in pancreatic ductal adenocarcinoma patients with diabetes.
제1저자 정광현 · 교신저자 황진혁
소속 (5)
- Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, 101, Daehak-ro, Jongno-gu, Seoul 110-744, Republic of Korea.
- Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital Healthcare System Gangnam Center, Gangnam Finance Center, 152, Teheran-ro, Gangnam-gu, Seoul 135-984, Republic of Korea.
- Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 82, Gumi-ro 173 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-707, Republic of Korea.
- Department of Surgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 82, Gumi-ro 173 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-707, Republic of Korea.
- Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 82, Gumi-ro 173 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-707, Republic of Korea. Electronic address: woltoong@snu.ac.kr.
Abstract
BACKGROUND The effects of diabetes mellitus (DM) on sensitivity of fluorine-18 fluorodeoxyglucose positron emission tomography coupled with computed tomography ((18)F-FDG PET/CT) for diagnosing pancreatic ductal adenocarcinomas (PDACs) is not well known. This study was aimed to evaluate the effects of DM on the validity of (18)F-FDG PET/CT in PDAC.
METHODS A total of 173 patients with PDACs who underwent (18)F-FDG PET/CT were enrolled (75 in the DM group and 98 in the non-DM group). The maximum standardized uptake values (SUVsmax) were compared.
RESULTS The mean SUVmax was significantly lower in the DM group than in the non-DM group (4.403 vs 5.998, P = .001). The sensitivity of SUVmax (cut-off value 4.0) was significantly lower in the DM group than in the non-DM group (49.3% vs 75.5%, P < .001) and also lower in normoglycemic DM patients (n = 24) than in non-DM patients (54.2% vs 75.5%, P = .038).
CONCLUSION DM contributes to a lower SUVmax of (18)F-FDG PET/CT in patients with PDACs.
Copyright © 2015 Elsevier Inc. All rights reserved.
Keywords
CarcinomaDiabetes mellitusPancreatic ductalPositron emission tomography and computed tomographyStandardized uptake value
그 밖의 정보
- 출판 형태
- Journal Article
- 저널
- American journal of surgery · eISSN 1879-1883
- 전자 출판
- 2014-12-24
- MeSH
- Aged · Carcinoma, Pancreatic Ductal / complications / diagnosis / metabolism · Diabetes Complications / diagnosis / metabolism · Female · Fluorodeoxyglucose F18 / pharmacokinetics · Humans · Male · Middle Aged · Multimodal Imaging · Pancreatic Neoplasms / complications / diagnosis / metabolism · Positron-Emission Tomography* · Retrospective Studies · Tomography, X-Ray Computed*
- Substances
- Fluorodeoxyglucose F18