Gut Liver. 2025;19(6):809-820.

Role of Serum Pepsinogen Tests in Detection of Gastric Atrophy, Intestinal Metaplasia, Gastric Adenoma, and Gastric Cancer in South Korea.

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제1저자 최용훈 · 교신저자 김나영

PMID 40443392 PMC12616145 DOI 10.5009/gnl250055 IF 4.1 소화기내과

소속 (3)

Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
Research Center for Sex- and Gender-Specific Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea.

Abstract

BACKGROUND/AIMS The aim of this study was to evaluate the efficacy of serum pepsinogen (sPG) tests for gastritis, gastric adenoma (GA), and gastric cancer (GC) using the enzyme‑linked immunosorbent assay-based GastroPanel kit and to investigate the correlation between Gastro-Panel- and Latex-enhanced Turbidimetric Immunoassay (L-TIA)-derived sPG results.

METHODS sPG I and II levels and PG I/II ratios were measured using both kits in 2,204 participants, including 1,109 controls, 316 GA, and 779 GC patients.

RESULTS The GastroPanel- and L-TIA-derived sPG results showed high concordance. An sPG I concentration of 70 ng/mL and a PG I/II ratio of 3 measured with the L-TIA kit corresponded to 100 ng/mL and 5.3 with the GastroPanel kit. sPG I decreased in the GA and GC groups, whereas sPG II was lower in the GA group, but higher in the GC group than that in control group. The PG I/II ratios significantly decreased in the GA and GC groups, especially for the intestinal type. The sensitivity and specificity of PG I/II ratio ≤5.3 using the GastroPanel kit for the detection of GA or GC were 51%-59% and 61%-66%, respectively, which were slightly higher than 51%-58% and 58%-63% using the L-TIA kit. The group with a PG I/II ratio ≤5.3 and Helicobacter pylori-negative status had the highest risk with an adjusted odds ratio of 3.36 for GA and 2.25 for GC, with more prominent increase in diffuse-type compared to intestinal-type.

CONCLUSIONS The GastroPanel kit showed non-inferiority compared to the L-TIA kit.

Keywords

Early detection of cancerHelicobacter pyloriPepsinogensStomach neoplasms

Figures

**Fig. 1** (A) sPG I, (B) sPG II, and (C) PG I/II ratio of participants according to histologic diagnosis. sPG, serum pepsinogen.

**Fig. 2** Receiver operating characteristic curve of sPG levels for diagnosing GA with (A-C) GastroPanel and (D-F) L-TIA. sPG, serum pepsinogen; L-TIA, Latex-enhanced Turbidimetric Immunoassay; ROC, receiver operating characteristic; AUC, area under the curve.

그림 출처: PubMed Central 공개 논문 (PMC12616145)

Conflict of interest statement

CONFLICTS OF INTEREST . This clinical study was supported by Dow Biomedica. However, funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.

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