BMC Cardiovasc Disord. 2019;19(1):98.

Association between dental health and obstructive coronary artery disease: an observational study.

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제1저자 이호 · 교신저자 김학령

PMID 31029089 PMC6487007 DOI 10.1186/s12872-019-1080-9 IF 3.1 순환기내과

소속 (5)

Section of Dentistry, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, South Korea.
Division of Cardiology, Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul National University College of Medicine, 20, Boramae-ro 5-gil, Dongjak-gu, Seoul, 07061, South Korea. khl2876@gmail.com.
Department of Radiology, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul, South Korea.
Department of Biostatistics, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul, South Korea.
Division of Cardiology, Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul National University College of Medicine, 20, Boramae-ro 5-gil, Dongjak-gu, Seoul, 07061, South Korea.

Abstract

BACKGROUND The association between dental health and coronary artery disease (CAD) remains a topic of debate. This study aimed to investigate the association between dental health and obstructive CAD using multiple dental indices.

METHODS Eighty-eight patients (mean age: 65 years, 86% male) were prospectively enrolled before undergoing coronary CT angiography (n = 52) or invasive coronary angiography (n = 36). Obstructive CAD was defined as luminal stenosis of ≥50% for the left main coronary artery or ≥ 70% for the other epicardial coronary arteries. All patients underwent thorough dental examinations to evaluate 7 dental health indices, including the sum of decayed and filled teeth, the ratio of no restoration, the community periodontal index of treatment needs, clinical attachment loss, the total dental index, the panoramic topography index, and number of lost teeth.

RESULTS Forty patients (45.4%) had obstructive CAD. Among the 7 dental health indices, only the number of lost teeth was significantly associated with obstructive CAD, with patients who had obstructive CAD having significantly more lost teeth than patients without obstructive CAD (13.08 ± 10.4 vs. 5.44 ± 5.74, p < 0.001). The number of lost teeth was correlated with the number of obstructed coronary arteries (p < 0.001). Multiple binary logistic regression analysis revealed that having ≥10 lost teeth was independently associated with the presence of obstructive CAD (odds ratio: 8.02, 95% confidence interval: 1.80-35.64; p = 0.006).

CONCLUSIONS Tooth loss was associated with the presence of obstructive CAD in patients undergoing coronary evaluation. Larger longitudinal studies are needed to determine whether there is a causal relationship between tooth loss and CAD.

Keywords

Coronary artery diseaseDental healthInflammationTooth loss

Figures

**Fig. 1** Linear association between CAD severity and number of lost teeth ANOVA, analysis of variance; VD, vessel disease; CAD, coronary artery disease

**Fig. 2** ROC curve analysis showing the cut-off value for number of lost teeth to predict obstructive coronary artery disease ROC, receiver-operating characteristic; AUC, area under curve; CI, confidence interval.

그림 출처: PubMed Central 공개 논문 (PMC6487007)

Conflict of interest statement

ETHICS APPROVAL AND CONSENT TO PARTICIPATE: The study’s protocol was approved by the institutional review board of Boramae Medical Center (# 16–2013-34) and complied with the tenets of the 1964 Declaration of Helsinki and its later amendments. Written informed consent was obtained from all participants. CONSENT FOR PUBLICATION: Not applicable. COMPETING INTERESTS: The authors declare that they have no competing interests. PUBLISHER’S NOTE: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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