Clin Lymphoma Myeloma Leuk. 2019;19(11):e605-e615.
Comparison of Different Conditioning Regimens in Allogeneic Hematopoietic Stem-Cell Transplantation Shows Superiority of Total Body Irradiation-Based Regimen for Younger Patients With Acute Leukemia: A Nationwide Study.
제1저자 박현경 · 교신저자 변자민, 고영일
소속 (7)
- Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea.
- Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. Electronic address: jaminbyun@naver.com.
- Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. Electronic address: go01@snu.ac.kr.
- Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.
- Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.
- National Evidence-Based Healthcare Collaborating Agency, Seoul, Korea.
- Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Korea.
Abstract
BACKGROUND The optimal the conditioning regimens for allogeneic hematopoietic stem-cell transplantation, especially for East Asian patients, remains unknown.
PATIENTS AND METHODS We collected and analyzed clinical and survival data of 4255 patients from the Korean National Health Insurance Claims Database.
RESULTS Between 1562 myeloablative conditioning and 2693 nonmyeloablative conditioning groups, the overall survival was not statistically different. However, in the myeloablative conditioning group, the overall survival of the total body irradiation-based regimen was better than that of chemotherapy-alone regimen (P = .005). In subgroup analysis, the superiority of the total body irradiation-based regimen was especially prominent in acute leukemia (P = .012 for acute myeloid leukemia; P = .005 for acute lymphoblastic leukemia) and for younger patients (< 50 years old vs. ≥ 50 years old, P = .015).
CONCLUSION Total body irradiation combination might be the best conditioning regimen for young patients undergoing hematopoietic stem-cell transplantation for acute leukemias in Korea.
Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.
Keywords
Acute leukemiaAsianMyeloablative conditioningNonmyeloablative conditioning
그 밖의 정보
- 출판 형태
- Journal Article, Research Support, Non-U.S. Gov't
- 저널
- Clinical lymphoma, myeloma & leukemia · eISSN 2152-2669
- 전자 출판
- 2019-08-26
- MeSH
- Adult · Aged · Female · Hematopoietic Stem Cell Transplantation* / adverse effects / methods · Humans · Leukemia, Myeloid, Acute / diagnosis / mortality / therapy · Male · Middle Aged · Myeloablative Agonists / administration & dosage · Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis / mortality / therapy · Prognosis · Recurrence · Republic of Korea · Transplantation Conditioning* / methods · Transplantation, Homologous · Treatment Outcome · Whole-Body Irradiation* / methods
- Substances
- Myeloablative Agonists