Clin Gastroenterol Hepatol. 2020;18(12):2837-2839.e2.
Association Between a Polymorphism in MBOAT7 and Chronic Kidney Disease in Patients With Biopsy-Confirmed Nonalcoholic Fatty Liver Disease.
제1저자 구보경 · 교신저자 김원
소속 (7)
- Division of Endocrinology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul Metropolitan Government Boramae Medical Center, Seoul, Korea.
- Division of Nephrology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul Metropolitan Government Boramae Medical Center, Seoul, Korea.
- Division of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul Metropolitan Government Boramae Medical Center, Seoul, Korea.
- Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California.
- Department of Bio-convergence Engineering, Korea University, Seoul, Korea.
- Department of Pathology, Seoul National University College of Medicine, Seoul Metropolitan Government Boramae Medical Center, Seoul, Korea.
- Division of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul Metropolitan Government Boramae Medical Center, Seoul, Korea. Electronic address: drwon1@snu.ac.kr.
Abstract
Nonalcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD) share risk factors, and recent meta-analysis confirmed that NAFLD is an independent risk factor for incident CKD.1 Genetic variants associated with NAFLD, such as patatin-like phospholipase domain-containing-3 (PNPLA3) rs7384092 and transmembrane 6 superfamily member 2 (TM6SF2) rs5854292,2 have been reported to be associated with renal function in NAFLD subjects.
Copyright © 2020 AGA Institute. Published by Elsevier Inc. All rights reserved.
그 밖의 정보
- 출판 형태
- Journal Article, Research Support, Non-U.S. Gov't
- 저널
- Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · eISSN 1542-7714
- 전자 출판
- 2019-09-20
- MeSH
- Acyltransferases / genetics · Biopsy · Genetic Predisposition to Disease · Humans · Lipase / genetics · Liver · Membrane Proteins / genetics · Non-alcoholic Fatty Liver Disease* / genetics · Polymorphism, Single Nucleotide · Renal Insufficiency, Chronic* / genetics
- Substances
- Membrane Proteins · Acyltransferases · MBOAT7 protein, human · Lipase