Gut Liver. 2024;18(1):165-173.

Clinical Significance of Venous Thromboembolism in Patients with Advanced Cholangiocarcinoma.

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제1저자 김주성, 백우현 · 교신저자 이상협, 이상국

PMID 37009669 PMC10791496 DOI 10.5009/gnl220477 IF 4.1 소화기내과

소속 (2)

Department of Internal Medicine and Liver Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
Department of Internal Medicine, Dongguk University Ilsan Hospital, Dongguk University College of Medicine, Goyang, Korea.

Abstract

BACKGROUND/AIMS Patients with active cancer frequently develop venous thromboembolism (VTE). However, there is little data about VTE in patients with advanced cholangiocarcinoma (CCA). Therefore, we investigated the clinical significance of VTE in patients with advanced CCA.

METHODS We analyzed the data of a total of 332 unresectable CCA patients diagnosed between 2010 and 2020 in this retrospective study. We investigated the incidence and risk factors for VTE, and its effect on survival in patients with advanced CCA.

RESULTS During a median follow-up of 11.6 months, 118 patients (35.5%) developed VTE. The cumulative incidence of VTE was 22.4% (95% confidence interval [CI], 0.18 to 0.27) at 3 months and 32.8% (95% CI, 0.27 to 0.38) at 12 months. Major vessel invasion was an independent risk factor for VTE (hazard ratio, 2.88; 95% CI, 1.92 to 4.31; p<0.001). Patients who developed VTE during follow-up had shorter overall survival than patients who did not (11.50 months vs 15.83 months, p=0.005). In multivariable analysis, VTE (hazard ratio, 1.58; 95% CI, 1.23 to 2.02; p<0.001) was associated with poor overall survival.

CONCLUSIONS Major vessel invasion is related to the occurrence of VTE in advanced CCA. The development of VTE significantly decreases the overall survival and is an important unfavorable prognostic factor for survival.

Keywords

Advanced stageCholangiocarcinomaPrognostic factorVenous thromboembolism

Figures

**Fig. 1** Study flowchart. CCA, cholangiocarcinoma; VTE, venous thromboembolism.

**Fig. 2** Cumulative incidence of venous thromboembolism.

**Fig. 3** Comparison of (A) progression-free survival and (B) overall survival between the venous thromboembolism (VTE) group and the non-VTE group.

**Fig. 4** Multistate model of state occupation probabilities during the entire follow-up period showing clinical course in patients with advanced cholangiocarcinoma at risk of venous thromboembolism (VTE) and death.

그림 출처: PubMed Central 공개 논문 (PMC10791496)

Conflict of interest statement

CONFLICTS OF INTEREST . No potential conflict of interest relevant to this article was reported.

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