BMC Pulm Med. 2017;17(1):5.
Characteristics associated with progression in patients with of nontuberculous mycobacterial lung disease : a prospective cohort study.
제1저자 김수정 · 교신저자 임재준
소속 (4)
- Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, School of Medicine, Ewha Womans University, Seoul, Republic of Korea.
- Department of Radiology, Seoul National University College of Medicine, Seoul, Republic of Korea.
- Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehak-Ro, Jongno-Gu, Seoul, 110-744, Republic of Korea.
- Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehak-Ro, Jongno-Gu, Seoul, 110-744, Republic of Korea. yimjj@snu.ac.kr.
Abstract
BACKGROUND Patients with distinctive morphotype were more susceptible to nontuberculous mycobacterial lung disease (NTM-LD). However, little is known about the association between body morphotype and progression of NTM-LD. The aim of this study was to elucidate predictors of NTM-LD progression, focusing on body morphotype and composition.
METHODS Data from patients with NTM-LD who participated in NTM cohort which started in 1 July 2011 were analyzed. Patients with more than 6 months of follow up were included for analysis. NTM-LD progression was defined as clinician-initiated anti-NTM treatment, based on symptomatic and radiologic aggravation. Body morphotype and composition was measured at entry to the cohort using bioelectrical impedance analysis.
RESULTS NTM-LD progressed in 47 out of 150 patients with more than 6 months of follow up. Patients with middle (adjusted hazard ratio [aHR], 2.758; 95% confidence interval [CI], 1.112-6.843) or lowest tertile (aHR, 3.084; 95% CI, 1.241-7.668) of abdominal fat ratio had a higher risk of disease progression compared with the highest tertile. Other predictors for disease progression were presence of cavity on chest computed tomography (aHR, 4.577; 95% CI, 2.364-8.861), and serum albumin level <3.5 g/dL (aHR, 12.943; 95% CI, 2.588-64.718).
CONCLUSIONS Progression of NTM-LD is associated with body composition. Lower abdominal fat ratio is an independent predictor of NTM-LD progression.
TRIAL REGISTRATION ClinicalTrials.gov, NCT01616745 Registered 25 March 2012.
Keywords
Abdominal fatAnthropometryBody compositionNontuberculous mycobacteria
Figures
그림 출처: PubMed Central 공개 논문 (PMC5216528)
그 밖의 정보
- 출판 형태
- Journal Article, Observational Study
- 저널
- BMC pulmonary medicine · eISSN 1471-2466
- 전자 출판
- 2017-01-05
- MeSH
- Abdominal Fat · Adiposity* · Aged · Anthropometry · Disease Progression* · Female · Humans · Leptin / blood · Logistic Models · Lung / diagnostic imaging / physiopathology · Male · Middle Aged · Mycobacterium Infections, Nontuberculous / diagnosis · Nontuberculous Mycobacteria / isolation & purification · Proportional Hazards Models · Prospective Studies · Republic of Korea · Sputum / microbiology · Tomography, X-Ray Computed · Tuberculosis, Pulmonary / diagnosis
- Substances
- Leptin
- 데이터
- ClinicalTrials.gov: NCT01616745
- 참고문헌
- 33편