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Metab Syndr Relat Disord. 2017;15(8):416-422.

Association Between Obesity and Chronic Kidney Disease, Defined by Both Glomerular Filtration Rate and Albuminuria, in Korean Adults.

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제1저자 김윤지 · 교신저자 임수

PMID 28832275 DOI 10.1089/met.2017.0053 IF 1.6 내분비대사내과
소속 (6)
  1. 1 Division of Endocrinology and Metabolism, Department of Internal Medicine, Mediplex Sejong Hospital , Incheon, South Korea .
  2. 2 Division of Nephrology and Hypertension, Department of Internal Medicine, Inha University College of Medicine , Incheon, South Korea .
  3. 3 Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine , Seongnam, South Korea .
  4. 4 Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University , Seoul, South Korea .
  5. 5 Department of Preventive Medicine, Yonsei University College of Medicine , Seoul, South Korea .
  6. 6 Department of Preventive Medicine, Cardiovascular and Metabolic Diseases Etiology Research Center, Yonsei University College of Medicine , Seoul, South Korea .

Abstract

BACKGROUND Chronic kidney disease (CKD) has often been defined based on glomerular filtration rate (GFR) alone. The Kidney Disease: Improving Global Outcomes guideline highlights albuminuria in the CKD definition. Thus, we investigated the association between obesity and CKD, as defined by both GFR and albuminuria, in Korean adults.

METHODS We used Korea National Health and Nutrition Examination Survey 2011-2014 data (N = 19,331, ≥19 years old) representing the national Korean population. CKD was classified by (1) estimated GFR (eGFR) < 60 mL/min/1.73 m2 (CKDGFR); (2) albumin-to-creatinine ratio (ACR) ≥30 mg/gram (CKDACR); and (3) eGFR < 60 mL/min/1.73 m2 or ACR ≥30 mg/gram (CKDRisk). Associations between obesity and each CKD category were evaluated using multivariate logistic regression analysis.

RESULTS The prevalence rates of CKDGFR, CKDACR, and CKDRisk were 2.2%, 6.7%, and 8.1%, respectively. Compared with the normal body mass index (BMI; 18.5-22.9 kg/m2) group, men with BMI ≥ 25 kg/m2 had 1.88 times greater risk of CKDGFR in the adjusted model [95% confidence interval (CI), 1.26-2.80; P = 0.002]; BMI was not significantly associated with CKDGFR in women. In contrast, both men and women with BMI ≥ 25 kg/m2 had 1.58 and 1.40 times higher risk of CKDACR (95% CI, 1.21-2.07 and 1.08-1.81, respectively, both P < 0.01). Obese men and women had 1.65 and 1.38 times higher risk of CKDRisk (95% CI, 1.29-2.12 and 1.09-1.75, respectively, both P < 0.01).

CONCLUSIONS Obesity was significantly associated with an increased ACR-based CKD risk. Longitudinal studies are needed to investigate the role of overweight and obesity in the development and progression of CKD.

Keywords

albuminuriachronic kidney diseaseglomerular filtration rateobesity

그 밖의 정보
출판 형태
Journal Article
저널
Metabolic syndrome and related disorders · eISSN 1557-8518
전자 출판
2017-08-23
MeSH
Adult · Aged · Aged, 80 and over · Albuminuria / diagnosis / epidemiology / etiology · Comorbidity · Female · Glomerular Filtration Rate* · Humans · Longitudinal Studies · Male · Middle Aged · Nutrition Surveys · Obesity / complications / epidemiology / physiopathology · Prevalence · Renal Insufficiency, Chronic / complications / diagnosis / epidemiology / physiopathology · Republic of Korea / epidemiology · Risk Factors · Young Adult