Cancers (Basel). 2021;13(7):cancers13071599.

Association between Lipid Profiles and the Incidence of Hepatocellular Carcinoma: A Nationwide Population-Based Study.

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제1저자 조유리, 조은주 · 교신저자 신동욱, 유수종

PMID 33808412 PMC8037932 DOI 10.3390/cancers13071599 IF 4.8 소화기내과

소속 (11)

Center for Liver and Pancreatobiliary Cancer, National Cancer Center, Goyang 10408, Korea.
Department of Internal Medicine, CHA Gangnam Medical Center, CHA University School of Medicine, Seoul 06135, Korea.
Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 03080, Korea.
Department of Gastroenterology and Hepatology, Soonchunhyang University Bucheon Hospital, Bucheon 14584, Korea.
Department of Gastroenterology and Hepatology, Soonchunhyang University Seoul Hospital, Seoul 04401, Korea.
Department of Internal Medicine, Healthcare Research Institute, Gangnam Healthcare Center, Seoul National University Hospital, Seoul 06236, Korea.
Department of Family Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul 07061, Korea.
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Department of Biostatistics, College of Medicine, The Soongsil University, Seoul 06978, Korea.
Department of Family Medicine, Samsung Medical Center Supportive Care Center, Samsung Comprehensive Cancer Center, Seoul 06351, Korea.
Department of Digital Health, SAIHST, Sungkyunkwan University; 81 Irwon-Ro Gangnam-gu, Seoul 06351, Korea.

Abstract

BACKGROUND AND AIMS Altered lipid metabolism has been implicated in the development of hepatocellular carcinoma (HCC). This study investigated the relationships between lipid profiles and HCC development.

METHODS Data were obtained from the Korean National Health Insurance Service from 2009 to 2017. Cox regression analysis was used to examine the hazard ratios of HCC in 8,528,790 individuals who had undergone health check-ups in 2009.

RESULTS During a median of 7.3 years follow-up, 26,891 incidents of HCCs were identified. The incidence of HCC (per 100,000 person-years) gradually decreased according to the increase in total-cholesterol and LDL-cholesterol; the incidence of HCC was 69.2, 44.0, 33.9, and 25.8 in quartile-1 (Q1), Q2, Q3, and Q4 population of total-cholesterol, and 63.6, 44.5, 37.2, and 28.3 in Q1, Q2, Q3, and Q4 population of LDL-cholesterol, respectively. Compared to Q1 of total-cholesterol, subjects in higher total-cholesterol levels were associated with a lower incidence of HCC (multiple covariates-adjusted hazard ratio (aHR): Q2 0.61; Q3 0.46; Q4 0.36). These associations were consistently observed in stratified subgroup analysis by the presence of liver cirrhosis or viral hepatitis.

CONCLUSIONS Low serum lipid levels were significantly associated with the increased risk of developing HCC. A low lipid profile might be an independent risk factor and preclinical marker for HCC.

Keywords

cholesterolhepatocellular carcinomalipid metabolismlow-density lipoprotein

Figures

**Figure 1** Cumulative incidence of HCC according to the quartiles of TC (A), TG (B), LDL-C (C), and HDL-C (D). HCC, hepatocellular carcinoma; TC, total cholesterol; TG, triglycerides; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol.

**Figure 2** Adjusted HRs of HCC incidence according to lipid profile classification stratified by the presence of LC (A) or VH (B). HR, hazard ratio; HCC, hepatocellular carcinoma; LC, liver cirrhosis; VH, viral hepatitis.

그림 출처: PubMed Central 공개 논문 (PMC8037932)

Conflict of interest statement

The authors declare no conflict of interest.

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