Clin Microbiol Infect. 2007;13(1):91-3.
The persistence of humoral and cellular immunities more than three decades after smallpox vaccination.
제1저자 김성한 · 교신저자 오명돈
소속 (1)
- Center for Infectious Diseases, National Institute of Health, Seoul, Republic of Korea.
Abstract
This study assessed the persistence of humoral (neutralising antibody titre to vaccinia virus) and cellular (immediate vaccinia-specific interferon (IFN)-gamma-producing T-cell) immunities to smallpox in a Korean population. Individuals who were vaccinated 25-60 years previously had higher neutralising antibody titres (geometric mean titre (GMT) 13.7; 95% CI 11.0-17.2) than vaccinia-naive individuals (GMT 6.7; 95% CI 5.5-8.0; p <0.001). However, there was no significant difference in cellular immunity between individuals vaccinated previously and vaccinia-naive individuals, and only 15% of the individuals vaccinated previously displayed an immediate IFN-gamma-producing effector-memory response in ELISPOT assays.
그 밖의 정보
- 출판 형태
- Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
- 저널
- Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · ISSN 1198-743X
- MeSH
- Adult · Antibodies, Viral / blood · Female · Humans · Interferon-gamma / biosynthesis · Korea · Male · Middle Aged · Neutralization Tests · Smallpox / immunology / prevention & control · Smallpox Vaccine / administration & dosage / immunology · T-Lymphocytes / immunology · Time Factors · Vaccination* · Vaccinia virus / immunology
- Substances
- Antibodies, Viral · Smallpox Vaccine · Interferon-gamma