SCI 발표논문

SCI 발표논문

← SCI 발표논문 목록

Sci Rep. 2023;13(1):7495.

Usefulness of the BACES score in nontuberculous mycobacterial pulmonary disease for various clinical outcomes.

, , , , , , , , ,

제1저자 김형준 · 교신저자 이재호

소속 (4)
  1. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
  2. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
  3. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea. jhlee7@snubh.org.
  4. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. jhlee7@snubh.org.

Abstract

A uniform prognostic marker is needed for nontuberculous mycobacterial pulmonary disease (NTM-PD) due to the diverse clinical course. We aimed to seek the utility of the BACES score, originally derived to predict all-cause mortality, for various outcomes. To calculate the BACES score, one point was given for each of the following factors: body mass index < 18.5 kg/m2, age ≥ 65 years, presence of cavities, elevated erythrocyte sedimentation rate, or male sex. The study included 681 patients, of whom 97 (14.2%), 189 (27.7%), 192 (28.2%), 143 (21.0%), 47 (6.9%), and 13 (1.9%) had BACES scores of 0 to 5. Those with greater BACES scores were more likely to experience dyspnea, body weight loss, and anorexia. With severe disease, the risk of disease progression increased while the rate of treatment culture conversion decreased. After adjustment of comorbidities, higher BACES score was independently associated with the risk of mortality from respiratory causes or infection. As a simple and efficient bedside tool for assessing the severity of NTM-PD, the BACES score has the potential to be utilized as a surrogate marker for uniform severity assessment.

© 2023. The Author(s).

Figures

Figure 1
Figure 1 Patient outcomes after diagnosis of NTM-PD. Patients with higher BACES scores have a lower probability of progression-free survival (a) and negative culture conversion after treatment (b). The probabilities of all-cause mortality (c) and mortality from respiratory cause or infection (d) were higher with a higher BACES score. P values were calculated using the log-rank test with Bonferroni adjustment for multiple comparisons. Abbreviation: NTM-PD, nontuberculous mycobacterial pulmonary disease.
Figure 2
Figure 2 Patient survival according to the achievement of culture conversion. The graphs show Kaplan–Meier curves according to the achievement of ≥ 3 consecutive negative culture conversions after treatment. Solid lines indicate achievement of culture conversion, while dashed lines indicate failure to achieve culture conversion. Achievement of negative culture conversion was not associated with all-cause mortality (a) but with mortality from respiratory cause or infection (b).

그림 출처: PubMed Central 공개 논문 (PMC10170159)

Conflict of interest statement

The authors declare no competing interests.

그 밖의 정보
출판 형태
Journal Article
저널
Scientific reports · eISSN 2045-2322
전자 출판
2023-05-09
MeSH
Humans · Male · Aged · Dyspnea · Anorexia · Body Mass Index · Disease Progression · Mycobacterium Infections, Nontuberculous* / diagnosis · Lung Diseases*
참고문헌
34편