ESC Heart Fail. 2021;8(4):2816-2825.

Heart failure and atrial fibrillation: tachycardia-mediated acute decompensation.

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제1저자 박진주 · 교신저자 최동주

PMID 33960144 PMC8318460 DOI 10.1002/ehf2.13354 IF 3.8 순환기내과

소속 (11)

Cardiovascular Center, Division of Cardiology, Seoul National University Bundang Hospital, Gumiro 166, Bundang, Seongnam, Republic of Korea.
Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Heart Research Center of Chonnam National University, Gwangju, Republic of Korea.
Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea.
Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
Department of Internal Medicine, the Catholic University of Korea, Seoul, Republic of Korea.
Department of Internal Medicine, Sungkyunkwan University College of Medicine, Seoul, Republic of Korea.
Division of Cardiology, Asan Medical Center, Seoul, Republic of Korea.
Department of Internal Medicine, Chungbuk National University College of Medicine, Cheongju, Republic of Korea.
Department of Internal Medicine, Kyungpook National University College of Medicine, Daegu, Republic of Korea.
Mediplex Sejong Hospital, Incheon, Republic of Korea.

Abstract

AIMS Tachycardia is a reversible event that may cause hemodynamic decompensation but may not necessarily cause direct damages to the myocardium. To evaluate the clinical outcomes of patients with heart failure (HF) and atrial fibrillation (AF), whose acute decompensation was tachycardia mediated.

METHODS AND RESULTS The Korean Acute Heart Failure registry was a prospective registry that consecutively enrolled 5625 patients with acute HF. Patients were classified into three groups according to the rhythm and aggravating factor: (i) 3664 (65.1%) patients with sinus rhythm (SR), (ii) 1033 (18.4%) patients with AF whose decompensation was tachycardia-mediated, AF-TM (+), and (iii) N = 928 (16.5%) patients with AF whose decompensation was not tachycardia-mediated, AF-TM (-). The primary outcomes were in-hospital and post-discharge 1 year all-cause mortality. At admission, the mean heart rate was 90.8 ± 23.4, 86.8 ± 26.8, and 106.3 ± 29.7 beats per minute for the SR, AF-TM (-), and AF-TM (+) groups, respectively. The AF-TM (+) group had more favourable characteristics such as de novo onset HF, less diabetes, ischaemic heart disease, and higher blood pressure than the AF-TM (-) group. In-hospital mortality rates were 5.1%, 6.5%, and 1.7% for SR, AF-TM (-), and AF-TM (+) groups, respectively. In logistic regression analysis, the AF-TM (+) group had lower in-hospital mortality after adjusting the significant covariates (odds ratio, 0.49; 95% confidence interval, 0.26-0.93). The mortality rate did not differ between SR and AF-TM (-) groups. During 1 year follow-up, 990 (18.5%) patients died. In univariate and multivariate Cox proportional regression analyses, there was no difference in 1-year all-cause mortality between the three groups.

CONCLUSIONS In patients with HF and AF, patients whose acute decompensation is tachycardia-mediated have better in-hospital, but similar post-discharge outcomes compared with those with SR or those with AF whose decompensation is not tachycardia-mediated.

CLINICAL TRIAL REGISTRATION ClinicalTrial.gov NCT01389843.

Keywords

Atrial fibrillationHeart failureOutcomesSinus rhythmTachycardiaTrigger

Figures

**Figure 1** Study population. AF‐TM (+), patients with atrial fibrillation (AF) whose decompensation was tachycardia mediated; AF‐TM (−), patients with AF whose decompensation was not tachycardia‐mediated; KorAHF, Korean Acute Heart Failure Registry.

**Figure 2** Natriuretic peptide levels and heart rate of the patients. (A) The AF‐TM (+) group had lowest B‐type natriuretic peptide level and N‐terminal pro‐B‐type natriuretic peptide levels at admission. (B) At admission, the AF‐TM (+) group had higher heart rate. However, the difference in heart rates became smaller at discharge and disappeared at 1 month after discharge between the groups. Abbreviation similar in *Figure* 1; BNP, B‐type natriuretic peptide level; NT‐proBNP, N‐terminal pro‐B‐type natriuretic peptide.

**Figure 3** Clinical outcomes. (A) In‐hospital mortality: the AF‐TM (+) group had lowest in‐hospital mortality. The results were similar under stratification by GWTG‐HF score. (B) 1 Year post‐discharge mortality: the mortality did not differ between the patients with sinus rhythm and atrial fibrillation (AF) (left panel). Under stratification by the trigger, the AF‐TM (+) group had the lowest mortality, and the AF‐TM (−) group the highest mortality (right panel). Abbreviation similar in *Figure* 1. GWTG‐HF, Get With the Guidelines‐Heart Failure.

그림 출처: PubMed Central 공개 논문 (PMC8318460)

Conflict of interest statement

The authors declare no conflict of interest.

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