Gut Liver. 2014;8(3):254-64.

Recent chemotherapy reduces the maximum-standardized uptake value of 18F-fluoro-deoxyglucose positron emission tomography in colorectal cancer.

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제1저자 이민종 · 교신저자 김지원

PMID 24827621 PMC4026642 DOI 10.5009/gnl.2014.8.3.254 IF 4.1 소화기내과

소속 (3)

Department of Internal Medicine and Liver Research Institute, Seoul National University Hospital, Seoul, Korea.
Department of Internal Medicine and Liver Research Institute, Seoul National University Hospital, Seoul, Korea, Departments of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Departments of Boramae Medical Center, Seoul National University College of Medicine, Seoul, Korea.

Abstract

BACKGROUND/AIMS The aim of this study was to evaluate the influence of recent chemotherapy on the patterns of the maximum-standardized uptake value (M-SUV) and sensitivity of (18)F-fluoro-deoxyglucose positron emission tomography/computed tomography ((18)F-FDG-PET/CT) in colorectal cancer.

METHODS We retrospectively analyzed the FDG-PET/CT of 509 patients who underwent surgery for colorectal cancer. Subgroup analysis was performed according to chemotherapy status; 401 patients were not treated with chemotherapy and 108 patients were treated with chemotherapy within 6 months prior to surgery. Pathologic analysis of the surgical specimen was used as the gold standard.

RESULTS The M-SUV was significantly lower in patients treated with chemotherapy than in those not treated with chemotherapy in pathologically confirmed same stages of disease. The difference in the sensitivity of the M-SUV according to chemotherapy status was greatest using a cutoff M-SUV value of 6.4 (p<0.001). The longest diameter of the primary tumor was the most important factor that correlated with M-SUV of the primary tumor irrespective of the chemotherapy effect (p<0.001). The M-SUV of the primary tumor was not an independent predictor of lymph node metastasis in colorectal cancer.

CONCLUSIONS The results indicate that the M-SUV of FDG-PET/CT should be interpreted in the context of concurrent chemotherapy.

Keywords

Colorectal neoplasmsDrug therapyFDG-PET/CT

Figures

**Fig. 1** Box and whisker plots of the maximum-standardized uptake value (M-SUV) in the primary tumor by chemotherapy status. The upper and lower end points of the whiskers represent the observed maximum and minimum, respectively. The upper and lower edges of the boxes represent the 75th and 25th percentiles, respectively. The line inside the box represents the median value. (A) Distribution of the M-SUV plotted against the American Joint Committee on Cancer (AJCC) 7th edition stage. (B) Distribution of the M-SUV plotted against growth type.

**Fig. 2** Curves showing the change in sensitivity according to the cut-off value of the maximum-standardized uptake value (M-SUV) in the primary tumor by chemotherapy status.

**Fig. 3** Plot of the maximum-standardized uptake value against the longest tumor diameter by chemotherapy status. The lines indicate the models generated by multivariate regression analysis. ○ Indicates a tumor not treated with chemotherapy, and ● indicates a tumor treated with chemotherapy. The difference between the two slopes was not significant (p=0.454).

**Fig. 4** Receiver operating characteristic curve for the maximum-standardized uptake value (M-SUV) of the primary tumor in the group of patients not treated with recent chemotherapy. The prediction of lymph node metastasis of the primary tumor by the M-SUV was not significantly accurate. Area under the curve, 0.540; 95% confidence interval, 0.482 to 0.598.

그림 출처: PubMed Central 공개 논문 (PMC4026642)

Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

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