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SCI 발표논문

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Sci Rep. 2022;12(1):18953.

Lack of the association between height and cardiovascular prognosis in hypertensive men and women: analysis of national real-world database.

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제1저자 김학령 · 교신저자 신진호, 성기철

소속 (5)
  1. Division of Cardiology, Department of Internal Medicine, Boramae Medical Center, Seoul National University College of Medicine, Seoul, South Korea.
  2. Division of Cardiology, Department of Internal Medicine, Hanyang University Guri Hospital, Gyeonggi-Do, South Korea.
  3. Center of Biomedical Data Science, Wonju College of Medicine, Yonsei University, Wonju, South Korea.
  4. Division of Cardiology, Department of Internal Medicine, Hanyang University College of Medicine, 222 Wangsimni-Ro Sungdong-Gu, Seoul, 04763, South Korea. jhs2003@hanyang.ac.kr.
  5. Division of Cardiology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 29 Saemunan-Ro, Jongno-Gu, Seoul, 03181, South Korea. kcmd.sung@samsung.com.

Abstract

Data on the association between height and cardiovascular risk are still conflicting. Moreover, no reports are showing this issue in hypertensive patients. This study was performed to investigate whether height affects cardiovascular prognosis in hypertensive patients using nation-wide real-world data. Using the Korean National Health Insurance Service database, we analyzed 461,492 Korean hypertensive patients without any prior history of cardiovascular disease between January 2002 and December 2017. The incidence of a composite of cardiovascular death, myocardial infarction, and stroke was assessed according to height quintiles. In univariable comparisons, the taller the patients, the younger the age and the higher the proportion of men. In multivariable cox regression analyses, height was not associated with the occurrence of cardiovascular events. Although the risk of clinical events increased in some height quintiles compared to the first height quintile, there was no tendency to increase the risk according to the increase in the height quintile. These results were similar even when men and women were analyzed separately. In the same quintile group of height, there were no significant differences in clinical outcomes between sexes. In Korean hypertensive patients, there was no association between height and the occurrence of cardiovascular events. This result did not differ by sex. The clinical use of height for CVD prediction seems to be still tricky in hypertensive patients.

© 2022. The Author(s).

Figures

Figure 1
Figure 1 Flow chart for the enrollment of study patients.
Figure 2
Figure 2 The risk of MACE and each cardiovascular event according to height quintile. MACE major adverse cardiovascular event.
Figure 3
Figure 3 The risk of MACE according to height quintile in men and women. MACE major adverse cardiovascular event.

그림 출처: PubMed Central 공개 논문 (PMC9643395)

Conflict of interest statement

The authors declare no competing interests.

그 밖의 정보
출판 형태
Journal Article
저널
Scientific reports · eISSN 2045-2322
전자 출판
2022-11-08
MeSH
Male · Humans · Female · Risk Factors · Hypertension* / epidemiology / complications · Body Height · Cardiovascular Diseases* / etiology · Prognosis · Myocardial Infarction* / complications
참고문헌
34편