Br J Cancer. 2018;118(9):1169-1175.
Predicting cumulative incidence of adverse events in older patients with cancer undergoing first-line palliative chemotherapy: Korean Cancer Study Group (KCSG) multicentre prospective study.
제1저자 김진원 · 교신저자 김지현
소속 (18)
- Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, South Korea.
- Department of Internal Medicine, Kangbuk Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
- Department of Internal Medicine, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, South Korea.
- Department of Internal Medicine, Dongsan Medical Center, Keimyung University, Daegu, South Korea.
- Department of Hematology and Oncology, Ulsan University Hospital, Ulsan University College of Medicine, Ulsan, South Korea.
- Department of Internal Medicine, Uijeongbu St. Mary's Hospital, Uijeongbu, South Korea.
- Department of Internal Medicine, Kosin University Gospel Hospital, Busan, South Korea.
- Department of Internal Medicine, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
- Department of Internal Medicine, National Health Insurance Service Ilsan Hospital, Goyang, South Korea.
- Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
- Research Institute and Hospital, National Cancer Center, Goyang, South Korea.
- Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, South Korea.
- Department of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang, South Korea.
- Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
- Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, South Korea.
- Department of Oncology, Asan Medical Center, Ulsan University College of Medicine, Seoul, South Korea.
- Department of Internal Medicine, Daegu Catholic University Hospital, Daegu, South Korea.
- Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, South Korea. jhkimmd@snu.ac.kr.
Abstract
BACKGROUND Older patients have increased risk of toxicity from chemotherapy. Current prediction tools do not provide information on cumulative risk.
METHODS Patients aged ≥ 70 years with solid cancer were prospectively enrolled. A prediction model was developed for adverse events (AEs) ≥ Grade 3 (G3), based on geriatric assessment (GA), laboratory, and clinical variables.
RESULTS 301 patients were enrolled (median age, 75 years). Median number of chemotherapy cycles was 4. During first-line chemotherapy, 53.8% of patients experienced AEs ≥ G3. Serum protein < 6.7 g/dL, initial full-dose chemotherapy, psychological stress or acute disease in the past 3 months, water consumption < 3 cups/day, unable to obey a simple command, and self-perception of poor health were significantly related with AEs ≥ G3. A predicting model with these six variables ranging 0-8 points was selected with the highest discriminatory ability (c-statistic= 0.646), which could classify patients into four risk groups. Predicted cumulative incidence of AEs ≥ G3 was discriminated according to risk groups.
CONCLUSIONS This prediction tool could identify the risk of AEs ≥ G3 after chemotherapy and provide information on the cumulative incidence of AEs in each cycle.
CLINICAL TRIAL ID WHO ICTRP number, KCT0001071.
Figures
그림 출처: PubMed Central 공개 논문 (PMC5943243)
Conflict of interest statement
The authors declare no competing interests.
그 밖의 정보
- 출판 형태
- Clinical Trial, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't
- 저널
- British journal of cancer · eISSN 1532-1827
- 전자 출판
- 2018-03-26
- MeSH
- Aged · Aged, 80 and over · Antineoplastic Agents / administration & dosage / adverse effects · Drug-Related Side Effects and Adverse Reactions / diagnosis / epidemiology · Female · Geriatric Assessment / methods · Humans · Incidence · Longitudinal Studies · Male · Neoadjuvant Therapy · Neoplasms / drug therapy / epidemiology · Palliative Care* · Prognosis · Republic of Korea / epidemiology · Risk Factors
- Substances
- Antineoplastic Agents
- 참고문헌
- 30편