Oral Surg Oral Med Oral Pathol Oral Radiol. 2013;116(1):55-60.
Clinical outcomes of radiation-based locoregional therapy in locally advanced head and neck squamous cell carcinoma patients not responding to induction chemotherapy.
제1저자 임유주 · 교신저자 김범석
소속 (1)
- Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.
Abstract
OBJECTIVE The purpose of this study was to evaluate the efficacy of radiation-based locoregional therapy for locally advanced head and neck squamous cell carcinoma (LA-HNSCC) patients who did not respond to induction chemotherapy (IC).
STUDY DESIGN Outcomes after radiation-based locoregional therapy were retrospectively analyzed.
RESULTS Among a total of 208 patients treated with IC, 46 (22.1%) did not respond. After IC, patients were treated with radiotherapy (RT), concurrent chemoradiotherapy (CCRT), or surgery with or without postoperative RT. Among the 46 nonresponders, 17 (37.8%) patients underwent surgery and 28 (62.2%) were treated with RT or CCRT. Responses to subsequent RT or CCRT for 26 evaluable patients were as follows: complete response=7 (26.9%), partial response=9 (34.6%), stable disease=4 (15.4%), and progressive disease=6 (23.1%).
CONCLUSION A significant proportion of LA-HNSCC patients who did not respond to IC can benefit from subsequent RT or CCRT.
Copyright © 2013 Elsevier Inc. All rights reserved.
그 밖의 정보
- 출판 형태
- Journal Article, Research Support, Non-U.S. Gov't
- 저널
- Oral surgery, oral medicine, oral pathology and oral radiology · eISSN 2212-4411
- 전자 출판
- 2013-04-06
- MeSH
- Adult · Aged · Carcinoma, Squamous Cell / drug therapy / radiotherapy / surgery · Combined Modality Therapy · Female · Head and Neck Neoplasms / drug therapy / radiotherapy / surgery · Humans · Induction Chemotherapy · Kaplan-Meier Estimate · Male · Middle Aged · Retrospective Studies · Treatment Outcome