J Hosp Infect. 2019;103(3):276-279.
Chlorhexidine sensitivity in staphylococci isolated from patients with central line-associated bloodstream infection.
제1저자 전강일 · 교신저자 김홍빈
소속 (9)
- Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Division of Infectious Diseases, Seoul National University Hospital, Seoul, Republic of Korea.
- Division of Infectious Diseases, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
- Infection Control Office, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
- Department of Laboratory Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
- Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Division of Infectious Diseases, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
- Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea.
- Department of Internal Medicine, Chungnam National University Hospital, Daejeon, Republic of Korea.
- Department of Internal Medicine, Chosun University Hospital, Gwangju, Republic of Korea.
- Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Division of Infectious Diseases, Seoul National University Bundang Hospital, Seongnam, Republic of Korea. Electronic address: hbkimmd@snu.ac.kr.
Abstract
Since 2011, 2% chlorhexidine in 70% isopropyl alcohol (2% chlorhexidine tincture) has been widely used in Korea. To investigate changes in chlorhexidine sensitivity of staphylococci causing central line-associated bloodstream infections, 264 blood culture isolates from adult patients treated in intensive care units of five university hospitals between 2008 and 2016 were analysed. We observed no significant changes in chlorhexidine minimum inhibitory and bactericidal concentrations, or in the prevalence of resistance-associated genes before and after introduction of 2% chlorhexidine tincture. Thus, there was no evidence of increased resistance to chlorhexidine in staphylococci causing central line-associated bloodstream infections.
Copyright © 2019 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.
Keywords
Central line-associated bloodstream infectionChlorhexidine resistanceMinimum bactericidal concentrationMinimum inhibitory concentrationStaphylococcus aureus
그 밖의 정보
- 출판 형태
- Journal Article
- 저널
- The Journal of hospital infection · eISSN 1532-2939
- 전자 출판
- 2019-07-15
- MeSH
- Adult · Aged · Aged, 80 and over · Bacteremia / microbiology · Catheter-Related Infections / microbiology · Catheterization, Central Venous / adverse effects · Chlorhexidine / pharmacology · Disinfectants / pharmacology · Female · Humans · Intensive Care Units · Korea · Male · Microbial Sensitivity Tests · Middle Aged · Staphylococcal Infections / microbiology · Staphylococcus / drug effects / isolation & purification
- Substances
- Disinfectants · Chlorhexidine