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Medicine (Baltimore). 2022;101(45):e31758.

Brachial-ankle pulse wave velocity as a predictor of long-term cardiovascular events in 2174 subjects with type 2 diabetes mellitus: A retrospective cohort study.

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제1저자 김학령, 전원경 · 교신저자 김학령

소속 (1)
  1. Division of Cardiology, Department of Internal Medicine, Boramae Medical Center, Seoul, National University College of Medicine, Seoul, Republic of Korea.

Abstract

The prognostic value of arterial stiffness in patients with diabetes mellitus (DM) remains unclear. The aim of this study was to investigate the association between brachial-ankle pulse wave velocity (baPWV) and the occurrence of cardiovascular events in people with DM. A total of 2714 subjects (mean age, 63.6 years; males, 59.3%) with type 2 DM and without documented cardiovascular disease and stroke were analyzed. The primary end-point of this study was composite cardiovascular events of cardiac death, non-fatal myocardial infarction, coronary revascularization and stroke. There were 118 composite events (4.3%) during a median follow-up period of 3.84 years (interquartile range, 1.60-5.52 years). In multivariable Cox regression analysis, higher baPWV (≥1672 cm/s) was associated with composite events even after controlling for potential confounders (hazard ratio [HR], 2.00; 95% confidence interval [CI], 1.31-3.07; P = .001). Compared to the lowest baPWV tertile, both middle (HR, 1.84; 95% CI, 1.03-3.27; P = .037) and the highest (HR, 2.97; 95% CI, 1.69-5.22; P < .001) tertile of baPWV were associated with increased risk of cardiovascular events in the same multivariable model. In conclusion, the baPWV was associated with cardiovascular events in people with type 2 DM. Considering the simplicity and convenience of baPWV measurement, baPWV may be useful for risk stratification of people with type 2 DM.

Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.

Figures

Figure 1.
Figure 1. Event free survival rate according to baPWV cutoff value. baPWV, brachial-ankle pulse wave velocity.
Figure 2.
Figure 2. Event free survival rate according to baPWV tertile. baPWV, brachial-ankle pulse wave velocity.

그림 출처: PubMed Central 공개 논문 (PMC9666137)

Conflict of interest statement

The authors have no funding and conflicts of interest to disclose.

그 밖의 정보
출판 형태
Journal Article
저널
Medicine · eISSN 1536-5964
MeSH
Male · Humans · Middle Aged · Pulse Wave Analysis · Ankle Brachial Index · Diabetes Mellitus, Type 2* / complications / epidemiology · Retrospective Studies · Predictive Value of Tests · Myocardial Infarction* / epidemiology · Stroke* / epidemiology
참고문헌
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