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Sci Rep. 2020;10(1):18260.

Prognostic impact of malignant diseases in idiopathic pulmonary fibrosis.

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제1저자 이홍열 · 교신저자 최선미

PMID 33106517 PMC7588444 DOI 10.1038/s41598-020-75276-2 IF 4.9 호흡기내과
소속 (2)
  1. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea.
  2. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea. sunmich81@gmail.com.

Abstract

No studies on idiopathic pulmonary fibrosis (IPF) have investigated the prognostic impact of extrapulmonary cancers in patients with IPF. We aimed to determine the prognostic impact of malignancies in patients with IPF. We retrospectively reviewed the medical records of patients diagnosed with IPF between 2001 and 2015. Patients were divided into three groups: IPF without cancer (n = 440), IPF with lung cancer (n = 69), and IPF with extrapulmonary cancer (n = 70). Of the 579 patients with IPF, 139 (24%) had cancer; the three most common types were lung (11.9%), gastric (2.4%), and colorectal (1.9%). Survival was significantly worse in patients with lung cancer than in those without cancer (hazard ratio [HR] = 1.83, 95% confidence interval [CI], 1.35-2.48) or those with extrapulmonary cancer (HR = 1.70, 95% CI, 1.14-2.54). The rate of hospitalisation for cancer-related complications was significantly higher in IPF patients with lung cancer than in those with extrapulmonary cancer. The annual rates of decline in percent predicted forced vital capacity and diffusion capacity for carbon monoxide did not differ among the groups. Physicians should pay attention to the development and progression of cancer and its prognostic impact in patients with IPF.

Figures

Figure 1
Figure 1 Kaplan–Meier curves for survival in patients with idiopathic pulmonary fibrosis (IPF) stratified by cancer status. (a) The IPF patients with lung cancer group are further classified into the early and advanced groups. (b) Subgroup analysis for survival in IPF patients with lung cancer according to the cancer stage at diagnosis (c) and first-line treatment after lung cancer diagnosis (d). IPF idiopathic pulmonary fibrosis.
Figure 2
Figure 2 Rates of emergency room visit and admission to the intensive care unit per 100 person-years. (a) The differences in the rates of emergency room (ER) visits per 100 person-years among the groups. I bars indicate the standard error. (b) The differences in the rates of admission to the intensive care unit (ICU) per 100 person-years among the groups. I bars indicate the standard error. IPF idiopathic pulmonary fibrosis.
Figure 3
Figure 3 Annual rates of absolute change from the baseline in FVC and DLCO. (a) The differences in the annual rates of absolute change in FVC among the groups. I bars indicate the standard error. (b) The differences in the annual rates of absolute change in percent predicted DLCO among the groups. I bars indicate the standard error. IPF idiopathic pulmonary fibrosis, FVC forced vital capacity, DLCO diffusing capacity of the lung for carbon monoxide, % pred percent predicted.

그림 출처: PubMed Central 공개 논문 (PMC7588444)

Conflict of interest statement

The authors declare no competing interests.

그 밖의 정보
출판 형태
Journal Article
저널
Scientific reports · eISSN 2045-2322
전자 출판
2020-10-26
MeSH
Aged · Databases, Factual · Disease Progression · Female · Humans · Idiopathic Pulmonary Fibrosis / complications / pathology · Lung Neoplasms / etiology / pathology · Male · Middle Aged · Neoplasms / etiology / pathology · Prognosis · Retrospective Studies · Risk Factors · Survival Rate · Tomography, X-Ray Computed / methods
참고문헌
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