Allergy Asthma Immunol Res. 2018;10(5):555-561.
The Fas Signaling Pathway Is a Common Genetic Risk Factor for Severe Cutaneous Drug Adverse Reactions Across Diverse Drugs.
제1저자 박흥우 · 교신저자 박흥우
소속 (10)
- Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
- Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, Korea. guinea71@snu.ac.kr.
- Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.
- Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
- Department of Internal Medicine, Eulji University School of Medicine, Daejeon, Korea.
- Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Korea.
- Department of Dermatology, Dongguk University Ilsan Hospital, Goyang, Korea.
- Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine, Seoul, Korea.
- Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea.
- Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, Korea.
Abstract
PURPOSE Human leukocyte antigen (HLA) has been recognized as the most important genetic risk factor for severe cutaneous adverse drug reactions (SCARs) caused by certain drugs. However, cumulated observations suggest the presence of genetic risk factors for SCARs other than drug-specific HLA. We aimed to identify a common genetic risk factor of SCARs across multiple drugs.
METHODS We performed 2 independent genome-wide association studies (GWASs). A total of 68 and 38 subjects with a diagnosis of SCAR were enrolled in each GWAS. Their allele frequencies were compared to those of healthy subjects in Korea.
RESULTS No single nucleotide polymorphism (SNP) with genome-wide significance was found in either GWAS. We next selected and annotated the 200 top-ranked SNPs from each GWAS. These 2 sets of annotated genes were then entered into the web interface of ConsensusPathDB for a pathway-level analysis. The Fas signaling pathway was significantly over-represented in each gene set from the 2 GWASs.
CONCLUSIONS Our observations suggest that the Fas signaling pathway may be a common genetic risk factor for SCARs across multiple drugs.
Copyright © 2018 The Korean Academy of Asthma, Allergy and Clinical Immunology · The Korean Academy of Pediatric Allergy and Respiratory Disease.
Keywords
DrugFas signaling pathwayStevens-Johnson syndromegenome-wide association studytoxic epidermal necrolysis
Conflict of interest statement
There are no financial or other issues that might lead to conflict of interest.
그 밖의 정보
- 출판 형태
- Journal Article
- 저널
- Allergy, asthma & immunology research · ISSN 2092-7355
- 참고문헌
- 24편