Cancer Res Treat. 2016;48(2):518-26.

VEGF and Ki-67 Overexpression in Predicting Poor Overall Survival in Adenoid Cystic Carcinoma.

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제1저자 박성열, 남수정 · 교신저자 김범석

PMID 26194375 PMC4843710 DOI 10.4143/crt.2015.093 IF 4.2 혈액종양내과

소속 (6)

Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Department of Pathology, Seoul National University College of Medicine, Seoul, Korea.
The Tumor Immunity Medical Research Center, Cancer Research Center, Seoul National University College of Medicine, Seoul, Korea.
Department of Pathology, National Cancer Center, Goyang, Korea.
Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.
Department of Otorhinolaryngology, Seoul National University College of Medicine, Seoul, Korea.

Abstract

PURPOSE The purpose of this study was to evaluate potential prognostic factors in patients with adenoid cystic carcinoma (ACC).

MATERIALS AND METHODS A total of 68 patients who underwent curative surgery and had available tissue were enrolled in this study. Their medical records and pathologic slides were reviewed and immunohistochemistry for basic fibroblast growth factor, fibroblast growth factor receptor (FGFR) 2, FGFR3, c-kit, Myb proto-oncogene protein, platelet-derived growth factor receptor beta, vascular endothelial growth factor (VEGF), and Ki-67 was performed. Univariate and multivariate analysis was performed for determination of disease-free survival (DFS) and overall survival (OS).

RESULTS In univariate analyses, primary site of nasal cavity and paranasal sinus (p=0.022) and Ki-67 expression of more than 7% (p=0.001) were statistically significant factors for poor DFS. Regarding OS, perineural invasion (p=0.032), high expression of VEGF (p=0.033), and high expression of Ki-67 (p=0.007) were poor prognostic factors. In multivariate analyses, primary site of nasal cavity and paranasal sinus (p=0.028) and high expression of Ki-67 (p=0.004) were independent risk factors for poor DFS, and high expression of VEGF (p=0.011) and Ki-67 (p=0.011) showed independent association with poor OS.

CONCLUSION High expression of VEGF and Ki-67 were independent poor prognostic factors for OS in ACC.

Keywords

Adenoid cystic carcinomaImmunohistochemistryKi-67PrognosisVascular endothelial growth factor

Figures

**Fig. 1.** Immunohistochemical staining of adenoid cystic carcinoma. (A) Low expression of vascular endothelial growth factor (VEGF). (B) High expression of VEGF. (C) Low expression of Ki-67. (D) High expression of Ki-67 (A-D, ×200).

**Fig. 2.** Kaplan-Meier curve for disease-free survival by vascular endothelial growth factor expression (A) and Ki-67 expression (B). Comparisons were made using the log-rank test.

**Fig. 3.** Kaplan-Meier curve for overall survival by vascular endothelial growth factor (VEGF) expression (A), Ki-67 expression (B), and VEGF and/or Ki-67 expression (C). Comparisons were made using the log-rank test.

그림 출처: PubMed Central 공개 논문 (PMC4843710)

Conflict of interest statement

Conflict of interest relevant to this article was not reported.

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