Hum Immunol. 2014;75(5):466-9.
CXCR3 polymorphism is associated with male gender and pleuritis in patients with systemic lupus erythematosus.
제1저자 임철현 · 교신저자 송영욱
소속 (3)
- Division of Rheumatology, Department of Internal Medicine, Seoul National University Medical College, Seoul, Republic of Korea.
- Center for Genomic Science, The National Institute of Health, Seoul, Republic of Korea. Electronic address: yeonmaru@gmail.com.
- Division of Rheumatology, Department of Internal Medicine, Seoul National University Medical College, Seoul, Republic of Korea; WCU Department of Molecular Medicine and Biopharmaceutical Sciences, Medical Research Center, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, 110-799 Seoul, Republic of Korea. Electronic address: ysong@snu.ac.kr.
Abstract
BACKGROUND Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease involving multiple organs. Chemokines and their receptors play an important role in the pathogenesis of SLE. Lymphocytes expressing CXCR3, chemokine receptors of CXCL4, 9, 10, and 11, increase in patients with SLE and animal models, particularly in those with skin manifestations and nephritis. We investigated CXCR3 genetic polymorphisms in patients with SLE and their association with clinical manifestations.
METHODS A total of 346 patients with SLE and 540 healthy controls were investigated for CXCR3 intron 1 polymorphisms rs2280964 and rs34334103 by Taqman analysis.
RESULTS rs2280964 and rs34334103 were not associated with all patients with SLE, but rs34334103 showed a significant association with male patients with SLE. Among the clinical manifestations, pleuritis was associated with the rs34334103 polymorphism.
CONCLUSION The CXCR3 polymorphism rs34334103 was associated with male gender and pleuritis in patients with SLE.
Copyright © 2014 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
그 밖의 정보
- 출판 형태
- Journal Article, Research Support, Non-U.S. Gov't
- 저널
- Human immunology · eISSN 1879-1166
- 전자 출판
- 2014-02-12
- MeSH
- Adult · Alleles · Case-Control Studies · Female · Genetic Association Studies · Genetic Predisposition to Disease* · Genotype · Haplotypes · Humans · Lupus Erythematosus, Systemic / complications / genetics · Male · Middle Aged · Odds Ratio · Pleurisy / etiology · Polymorphism, Genetic* · Receptors, CXCR3 / genetics · Sex Factors · Young Adult
- Substances
- Receptors, CXCR3