J Am Geriatr Soc. 2016;64(3):510-7.
Association Between Small Decrease in Serum Sodium Concentration within the Normal Range and All-Cause and Cardiovascular Mortality in Elderly Adults over 5 Years.
제1저자 안신영 · 교신저자 진호준
소속 (5)
- Department of Internal Medicine, Seoul National University Bundang Hospital, Seong-Nam, Korea.
- Department of Immunology, Postgraduate School, Seoul National University, Seoul, Korea.
- Department of Internal Medicine, Seoul National University, Seoul, Korea.
- Department of Psychiatry, Seoul National University, Seoul, Korea.
- Renal Institute, Clinical Research Center, College of Medicine, Seoul National University, Seoul, Korea.
Abstract
OBJECTIVES To determine the importance of a decrease in serum sodium concentration within the normal range in elderly adults.
DESIGN Prospective cohort.
SETTING The Korean Longitudinal Study on Health and Aging.
PARTICIPANTS Randomly selected, community-based elderly population with a corrected serum sodium level between 135.0 and 145.0 mEq/L (N = 949).
MEASUREMENTS Survival status was determined during 63.3 ± 16.6 months of follow-up.
RESULTS Participants were divided into corrected sodium groups as follows: 73 (7.7%) in Group 1 (sodium 135.0-138.0 mEq/L), 635 (66.9%) in Group 2 (sodium 138.1-142.0 mEq/L), and 241 (25.4%) in Group 3 (sodium 142.1.0-145.0 mEq/L). There were 34 (46.6%) deaths in Group 1, 124 (19.5%) in Group 2, and 52 (21.6%) in Group 3 (P < .001). In a Cox proportional hazards analysis, a 2-mEq/L higher sodium level reduced the risk of death by 14.9% (95% confidence interval (CI) = 0.1-27.4%, P = .048). Group 1 had risk of mortality that was 2.7 times as high as that of Group 2 (95% CI = 1.76-4.11, P < .001). Participants with a measured sodium level of 138.0 mEq/L or less and a corrected sodium level greater than 138.0 mEq/L had a better survival rate than those with a measured sodium level of 138.0 mEq/L or less and a corrected sodium level of 138.0 mEq/L or less.
CONCLUSION A slightly lower serum sodium concentration within the normal range was a major risk factor for mortality in elderly adults. Sodium level corrected according to serum glucose concentration was a more meaningful risk factor than measured sodium level.
© 2016, Copyright the Authors Journal compilation © 2016, The American Geriatrics Society.
Keywords
elderly populationmortalitysodium
그 밖의 정보
- 출판 형태
- Journal Article, Research Support, Non-U.S. Gov't
- 저널
- Journal of the American Geriatrics Society · eISSN 1532-5415
- MeSH
- Aged · Aged, 80 and over · Blood Glucose / analysis · Cardiovascular Diseases / blood / mortality · Cause of Death · Female · Humans · Hyponatremia / blood / mortality · Longitudinal Studies · Male · Proportional Hazards Models · Prospective Studies · Reference Values · Republic of Korea · Risk Factors · Sodium / blood · Survival Rate
- Substances
- Blood Glucose · Sodium