Antimicrob Agents Chemother. 2016;60(11):6928-6932.
Association between Type A blaZ Gene Polymorphism and Cefazolin Inoculum Effect in Methicillin-Susceptible Staphylococcus aureus.
제1저자 이선희, 박완범 · 교신저자 이신원
소속 (6)
- Department of Internal Medicine, Pusan National University School of Medicine and Medical Research Institute, Pusan National University Hospital, Busan, Republic of Korea.
- Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
- Department of Internal Medicine, Pusan National University School of Medicine and Medical Research Institute, Pusan National University Hospital, Busan, Republic of Korea ebenezere.lee@gmail.com.
- Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Republic of Korea.
- Department of Internal Medicine, Daegu Fatima Hospital, Daegu, Republic of Korea.
- Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
Abstract
Some proportion of type A blaZ gene-positive methicillin-susceptible Staphylococcus aureus strains exhibit the cefazolin inoculum effect (CIE). The type A blaZ gene was divided into two groups by single nucleotide polymorphisms (SNPs) at Ser226Pro and Cys229Tyr. The median cefazolin MICs at a high inoculum concentration were 5.69 μg/ml for the Ser-Cys group and 40.32 μg/ml for the Pro-Tyr group (P = 0.01). The SNPs at codons 226 and 229 in the amino acid sequence encoded by the blaZ gene were closely associated with the CIE.
Copyright © 2016, American Society for Microbiology. All Rights Reserved.
그 밖의 정보
- 출판 형태
- Journal Article, Research Support, Non-U.S. Gov't
- 저널
- Antimicrobial agents and chemotherapy · eISSN 1098-6596
- 전자 출판
- 2016-10-21
- MeSH
- Anti-Bacterial Agents / pharmacology · Bacterial Proteins / genetics · Cefazolin / pharmacology · Cysteine / genetics · Dipeptides / genetics · Humans · Methicillin / pharmacology · Microbial Sensitivity Tests · Phylogeny · Polymorphism, Single Nucleotide* · Serine / genetics · Staphylococcus aureus / drug effects / genetics / isolation & purification
- Substances
- Anti-Bacterial Agents · Bacterial Proteins · Dipeptides · prolyl-tyrosine · Serine · Cefazolin · Cysteine · Methicillin
- 참고문헌
- 27편