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JACC Asia. 2026;6(2):249-252.

Rebound Phenomenon of Platelet Reactivity After Cessation of Long-Term Clopidogrel Therapy.

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제1저자 한정규 · 교신저자 한정규

PMID 41636403 PMC12904822 DOI 10.1016/j.jacasi.2025.12.004 IF 6.1 순환기내과
소속 (4)
  1. Cardiovascular Center, Seoul National University Hospital, Seoul, Republic of Korea; Department of Internal Medicine, College of Medicine, Seoul National University, Seoul, Republic of Korea. Electronic address: hpcrates@gmail.com.
  2. Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Republic of Korea.
  3. Cardiovascular Center, Seoul National University Hospital, Seoul, Republic of Korea.
  4. Cardiovascular Center, Seoul National University Hospital, Seoul, Republic of Korea; Department of Internal Medicine, College of Medicine, Seoul National University, Seoul, Republic of Korea.

Keywords

P2Y(12) receptorPRUclopidogrelplatelet functionrebound phenomenon

Figures

Figure 1
Figure 1 Rebound Phenomenon of Platelet Reactivity After Stopping Long-Term Clopidogrel Therapy (A) Study flow. (B) Increase in P2Y12 receptor protein expression levels in platelets from baseline to the time of clopidogrel cessation after ≥12 months of therapy. Six patients with P2Y12 levels below the lower detection limit of the standard curve were recorded as zero. (C) Increase in platelet reactivity unit (PRU) levels from baseline to 1 month after the cessation of clopidogrel therapy. (D) The percentages of patients with PRU levels ≥208 (left) or ≥252.5 (right) at baseline and 1 month after the cessation of clopidogrel therapy. The Wilcoxon signed rank test was used for panel B, paired t test for panel C, and chi-square tests for panel D. The red boxes and whiskers represent the median (Q1-Q3) and 1.5× Q1 to Q3 range, respectively, while red dots and error bars represent the mean ± SD. ELISA = enzyme-linked immunosorbent assay.

그림 출처: PubMed Central 공개 논문 (PMC12904822)

Conflict of interest statement

Funding Support and Author Disclosures This study was supported by a grant from the Korean Society of Interventional Cardiology (2020-04). The authors have reported that they have no relationships relevant to the contents of this paper to disclose.

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JACC. Asia · eISSN 2772-3747
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