SCI 발표논문

2011년 177편

1472011

제1저자 남현진 · 교신저자 방영주, 오도연

Nam H-J, Kim H-P, Yoon Y-K, Hur H-S, Song S-H, Kim M-S, Lee G-S, Han S-W, Im S-A, Kim T-Y, Oh D-Y, Bang Y-J
Antitumor activity of HM781-36B, an irreversible Pan-HER inhibitor, alone or in combination with cytotoxic chemotherapeutic agents in gastric cancer
Cancer Letters. 2011;302(2):155-165.

IF 3.741 혈액종양내과
1462011

제1저자 성수아 · 교신저자 오국환

Sung SA, Hwang YH, Kim S, Kim SG, Oh J, Chung W, Lee SY, Ahn C, Oh KH
Loss of residual renal function was not associated with glycemic control in patients on peritoneal dialysis
Perit Dial Int. 2011;31:154-159.

IF 1.636 신장내과
1452011

제1저자 유수종 · 교신저자 윤정환

Yu SJ, Yooon JH, Lee JH, Myung SJ, Jang ES, Kwak MS, Cho EJ, Jang JJ, Kim YJ, Lee HS
Inhibition of hypoxia-inducible carbonic anhydrase-Ⅸ enhances hexokinase Ⅱ inhibitor-induced hepatocellular carcinoma cell apoptpsis
Acta Pharmacologica Sinica. 2011;32:912-920.

IF 1.909 소화기내과
1442011

제1저자 임수 · 교신저자 고광곤

Lim S, Choi SH, Shin HI, Cho SI, Song JH, Park KS, KwaK SH, Lee HK, Kang SM, Jang HC, Yoon JW, Kok KK
Increasing Prevalence of Metabolic Syndrome in Korea
Diabetes Care. 2011;34:1323-1328.

IF 7.141 내분비대사내과
1432011

제1저자 임수, 강선미 · 교신저자 장학철

Lim S, Kang SM, Lee HJ, Yoon JW, Yu SH, Kim SY, Yoo SY, Jung HS, Park KS, Ryu JO, Jang HC
Improved Glycemic Control Without Hypoglycemia in Elderly Diabetic Patients Using the Ubiquitous Healthcare Serivce, a New Medical Information System
Diabetes Care. 2011;34:308-313.

IF 6.718 내분비대사내과
1422011

제1저자 신철민 · 교신저자 김나영

Shin CM, Kim NY, Cho SI, Kim JS, Jung HC, Song IS
Association between alcohol intake and risk for gastric cancer with regard to ALDH2 genotypr in the Korean population
Intern J Epidemiol. 2011;40(4):1047-1055.

IF 5.759 소화기내과
1412011

제1저자 이진솔 · 교신저자 김윤준

Lee JS, Kim JH, Park BL, Cheong HS, Koh IS, Kim YH, Park TJ, Charisse Flerida Pasaje, Bae JS, Lee HS, Kim YJ, Shin HD
No associations of polymorphisms in ADPRT with hepatitis B virus clearance and hepatocellular carcinoma occurrence in a Korean population
Hepatology Reasearch. 2011;41(3):250-7.

IF 1.857
1402011

제1저자 김의석 · 교신저자 김홍빈

Kim ES, Lee HJ, Chung GT, Lee YS, Shin DH, Jung SI, Song KH, Park WB, Kim NJ, Park KU, Kim EC, Oh MD, Kim HB
Molecular Characterization of Methicillin-Resistant Staphylococcus aureus Isolates in Korea
J Clin Microbiol. 2011;49:1979-1982.

IF 4.162 감염내과
1392011

제1저자 장은선 · 교신저자 정숙향

Jang ES, Won JE, Jung JI, Lee SH, Kim JW, Jeong SH
The effect of antivural therapy on serum cholesterol levels in chronic hepatitis C.
Gut Liver. 2011;5(3):356-62.

IF 0.219 소화기내과
1382011

제1저자 우현구 · 교신저자 김윤준

Woo HG, Park ES, Thorgeirsson SS, Kim YJ
Exploring genomic profiles of hepatocellular carcinoma
Molecular Carcinogenesis. 2011;50(4):235-243.

IF 3.202 소화기내과
1372011

제1저자 신동엽 · 교신저자 이세훈

Shin DY, Jeon YK, Hong YS, Kim TM, Lee SH, Kim DW, Kim IH, Yoon SS, Heo DS, Park SY, Kim BK
Clinical dissection of multicentric Castleman disease
Leukemia and Lymphoma. 2011;52(8):1517-1522.

IF 2.492 혈액종양내과
1362011

제1저자 이신원 · 교신저자 박완범

Lee SW, Choe PG, Song KH, Park SW, Kim HB, Kim NJ, Kim EC, Park WB, Oh MD
Is Cefazolin Inferior to Nafcillin for Treatment of MSSA Bacteremia?
Antimicrobial Agents and Chemotherapy. 2011;55(11):5122-5126.

IF 4.672 감염내과
1352011

제1저자 정고은 · 교신저자 김원

Chung GE, Kim W, Lee KL, Hwang SY, Lee JH, Kim HY, Jung YJ, Kim D, Jeong JB, Kim BG, Kim YJ, Yoon JH, Lee HS
Add-on adefovir is superior to a switch to entecavir as rescue therapy for Lamivudine-resistant chronic hepatitis B
Digestive Diseases and Sciences. 2011;56(7):2130-6.

IF 1.838 소화기내과
1342011

제1저자 구본권 · 교신저자 James K Min

Koo BK, Andrejs Erglis, Doh JH, David V.Daniels, Sanda Jegere, Kim HS, Allison Dunning, Tony DeFrance, Alexandra Lansky, Jonathan Leipsic, James K. Min
Diagnosis of Ischemia-Causing Coronary Stenoses by Noninvasive Fractional Flow Reserve Computed From Coronary Computed Tomographic Angiograms Results From the Prospective Multicenter DISCOVER-FLOW (Diagnosis of Ischemia-Causing Stenoses Obrained Via Noninvasive Fractional Flow Feserve) Study
J Am Coll Cardiol. 2011;58:1989-1997.

IF 14.292 순환기내과
1332011

제1저자 곽민선 · 교신저자 이정훈

Kwak MS, Lee JH, Chung GE, Yu SJ, Jung EU, Kim BH, Choi DH, Kim HY, Kim SH, Lee JM, Lee JY, Kim YJ, Yoon JH, Lee HS
Low P2/MS value is an independent risk factor for early recurrence of hepatocellular carcinoma after radiofrequency ablation therapy
Hepato-gastroenterology. 2011;58(105):147-152.

IF 0.669 소화기내과
1322011

제1저자 이상엽 · 교신저자 정숙향

Lee SH, Choi HC, Jeong SH, Lee KH, Chung JI, Park YS, Hwang JH, Kim JW, Kim N, Lee DH, Choi HC, Yoon CJ, Kang SG
Hepatocellular carcinoma in older adults: clinical features, treatments, and survival
J Am Geriatr Soc. 2011;59:241.

IF 3.656 소화기내과
1312011

제1저자 임수, 윤지완 · 교신저자 박경수

Lim S, Yoon JW, Kang SM, Choi SH, Cho BJ, Kim M, Park HS, Cho HJ, Shin HI, Kim YB, Kim HS, Jang HC, Park KS
EGb761, a Ginkgo Biloba Extract, Is Effective Against Atherosclerosis In Vitro, and in a Rat Model of Type 2 Diabetes
PLOS one. 2011;6:e20301.

IF 4.411 내분비대사내과
1302011

제1저자 박진현 · 교신저자 오도연

Park JH, Han SW, Oh DY, Im SA, Jeong SY, Park KJ, Kim TY, Bang YJ, Park JG
Analysis of KRAS, BRAF, PTEN, IGFIR, EGFR intron 1 CA status in both primary tumors and paired metastases in determining benefit from cetuximab therapy in colon cancer
Cancer Chemother and Pharmacology. 2011;68:1045-1055.

IF 2.759 혈액종양내과
1292011

제1저자 임규형 · 교신저자 오도연

Lim KH, Kim TY, Lee KH, Han SW, Oh DY, Im SA, Kim TY, Bang YJ
Efficacy of infusional 5-fluorouracil, doxorubicin, and mitomycin-C (iFAM) in the treatment of patients with gemcitabine-pretreated pancreatic cancer and analysis of prognostic factors in a salvage setting
Cancer Chemother Pharmacol. 2011;68(4):1017-26.

IF 2.654 혈액종양내과
1282011

제1저자 최정민 · 교신저자 김상균

Choi J, Kim SG, Im JP, Kim JS, Jung HC, Song IS
Endoscopic prediction of tumor invasion depth in early gastric cancer
Gastrointest Endosc. 2011;73(5):917-27.

IF 6.713 소화기내과
1272011

제1저자 이승표 · 교신저자 김효수

Lee SP, Bae JW, Park KW, Rha SW, Bae JH, Suh JW, Chae IH, Cho MC, Kim HS
Inhibitory Interaction Between Calcium Channel Blocker and Clopidogrel
Circ J. 2011;75:2581-2589.

IF 3.225 순환기내과
1262011

제1저자 윤혜선 · 교신저자 정숙향

Yun HS, Lee HJ, Jang JH, Kim JS, Lee SH, Kim JW, Park SJ, Park YM, Hwang SG, Rim KS, Kang SK, Lee HS, Jeong SH
Hepatitis A VIrus Genotype and Its Correlation With the Clinical Outcome of Acute Hepatitis Ain Korea: 2006-2008
J. Med. Virol 83. 2011;83:2073-2081.

IF 2.895 소화기내과
1252011

제1저자 박현경 · 교신저자 방수미

Park HK, Lee KR, Kim YJ, Cho HI, Kim JE, Kim KW, Kim YJ, Lee KW, Kim JH, Bang SM, Lee JS
Prevalence of monoclonal gammopathy of undetermined significance in an elderly urban Korean population
Am J Hematol. 2011;86(9):752-5.

IF 1.882 혈액종양내과
1242011

제1저자 방수미 · 교신저자 오도연

Jang MJ, Bang SM, Oh DY
Incidence of venous thromboembolism in Korea: from the Health Insurance Review and Assessment Service database
J Thromb Haemost. 2011;9(1):85-91.

IF 5.148 혈액종양내과
1232011

제1저자 박경우 · 교신저자 김효수

Park KW, Park JJ, Lee SP, Oh I-Y, Suh J-W, Yang H-M, Lee H-Y, Kang H-J, Cho Y-S, Koo B-K, Youn T-J, Chae I-H, Choi D-J, Oh B-H, Park Y-B, Kim H-S
Cilostazol attenuates on-treatment platelet reactivity in patients with CYP2C 19 loss of function alleles receiving dual antiplatelet therapy: a genetic substudy of the CILON-T randomised controlled trial.
Heart. 2011;97(8):641-647.

IF 5.385 순환기내과
1222011

교신저자 방영주

, ,
Epigenetic-based therapies in cancer: progress to date.
Drugs. 2011;71(18):2391-403.

Abstract
Epigenetic gene silencing is a hallmark of cancer cells. Two important types of epigenetic changes are DNA methylation and histone modification. These modifications are catalysed by DNA methyltransferases (DNMTs) and histone deacetylases (HDACs), resulting in chromatin structure changes and gene inactivation. Interestingly, inhibition of these enzymes is known to induce differentiation or apoptosis of cancer cells. Therefore, DNMTs and HDACs have become attractive therapeutic targets. In recent years, many different DNMT and HDAC inhibitors have been developed, and multiple molecular mechanisms through which these agents exert anti-cancer effects have been identified. While a large number of clinical trials are ongoing, hypomethylating agents and HDAC inhibitors seem to be promising for treating several types of cancer. Moreover, developing effective strategies of combining epigenetic therapy with conventional chemotherapy will be one of the major challenges in the future. We briefly review current advances in epigenetic therapies with a focus on recently reported clinical trials.
PubMed IF 14.7 혈액종양내과
1212011

제1저자 강은하 · 교신저자 송영욱

, , , ,
Salivary cytokine profiles in primary Sjögren's syndrome differ from those in non-Sjögren sicca in terms of TNF-α levels and Th-1/Th-2 ratios.
Clin Exp Rheumatol. 2011;29(6):970-6.

Abstract
OBJECTIVES To compare salivary cytokine profiles in patients with primary Sjögren's syndrome (pSS), non-SS sicca controls, and non-sicca controls, and to investigate whether cytokine levels are correlated with clinical parameters of pSS patients.
METHODS Un-stimulated whole saliva samples were obtained from pSS patients (n=30) classified according to the criteria of the American European Consensus Group. Age- and gender-matched non-SS sicca patients (n=30) and non-sicca subjects (n=25) served as controls. Salivary IFN-γ, TNF-α, IL-1, IL-4, IL-6, IL-10, IL-12p40, and IL-17 levels were measured using a multiplex Luminex® bead-based assay.
RESULTS pSS patients and non-SS sicca controls had significantly lower salivary flow rates (SFRs) than non-sicca controls, and pSS patients showed a more profound decrease than non-SS sicca controls. In addition, pSS patients and non-SS sicca controls had higher levels of IFN-γ, TNF-α, IL-1, IL-4, IL-10, IL-12p40, and IL-17 in their saliva than non-sicca controls. Salivary TNF-α levels were higher in pSS patients than in non-SS sicca controls. Th-1/Th-2 ratios, represented by INF-γ/IL-4 and TNF-α /IL-4 ratios, were significantly higher in pSS patients than in non-SS sicca controls. SFR was found to be correlated with INF-γ/IL-4 ratio (r=0.411 p=0.024), and focus score to be correlated with TNF-α/IL-4 ratio (r=0.581, p=0.023) in pSS patients.
CONCLUSIONS Th-1, Th-2, and Th17 cytokine levels were found to be elevated in the saliva of pSS patients compared with non-sicca controls. However, considerable overlap was observed between the salivary cytokine levels of pSS patients and of non-SS sicca controls. The features that most differentiated pSS and non-SS sicca were higher TNF-α levels and Th-1/Th-2 ratios. Th-1/Th-2 ratio was also found to be correlated with the clinical parameters of pSS.
PubMed IF 3.2 류마티스내과
1202011

제1저자 박정훈 · 교신저자 김태유

, , , , , , , , , ,
Identification of DNA methylation changes associated with human gastric cancer.
BMC Med Genomics. 2011;4:82.

Abstract
BACKGROUND Epigenetic alteration of gene expression is a common event in human cancer. DNA methylation is a well-known epigenetic process, but verifying the exact nature of epigenetic changes associated with cancer remains difficult.
METHODS We profiled the methylome of human gastric cancer tissue at 50-bp resolution using a methylated DNA enrichment technique (methylated CpG island recovery assay) in combination with a genome analyzer and a new normalization algorithm.
RESULTS We were able to gain a comprehensive view of promoters with various CpG densities, including CpG Islands (CGIs), transcript bodies, and various repeat classes. We found that gastric cancer was associated with hypermethylation of 5' CGIs and the 5'-end of coding exons as well as hypomethylation of repeat elements, such as short interspersed nuclear elements and the composite element SVA. Hypermethylation of 5' CGIs was significantly correlated with downregulation of associated genes, such as those in the HOX and histone gene families. We also discovered long-range epigenetic silencing (LRES) regions in gastric cancer tissue and identified several hypermethylated genes (MDM2, DYRK2, and LYZ) within these regions. The methylation status of CGIs and gene annotation elements in metastatic lymph nodes was intermediate between normal and cancerous tissue, indicating that methylation of specific genes is gradually increased in cancerous tissue.
CONCLUSIONS Our findings will provide valuable data for future analysis of CpG methylation patterns, useful markers for the diagnosis of stomach cancer, as well as a new analysis method for clinical epigenomics investigations.
PubMed IF 2.6 혈액종양내과
1192011

제1저자 곽민선 · 교신저자 이효석

, , , , , , ,
Predictors of HBsAg seroclearance in HBeAg-negative chronic hepatitis B patients.
Digestion. 2011;84 Suppl 1:23-8.

Abstract
BACKGROUND AND AIMS In chronic hepatitis B virus (HBV) infections, hepatitis B surface antigen (HBsAg) seroclearance reportedly occurs at a rate of 0.50-2.26%. Several factors were suggested to be associated with seroclearance including age and HBeAg negativity. However, there are few studies evaluating whether HBV DNA levels are an independent predictor of HBsAg seroclearance. The aim of this study was to evaluate the annual HBsAg seroclearance rate and its predictors including serum HBV DNA levels in HBeAg-negative chronic hepatitis B patients.
METHODS We included 880 HBeAg-negative chronic hepatitis B patients who underwent an evaluation of baseline serum HBV DNA levels. We reviewed the electronic charts for baseline clinical, biochemical, and virological factors.
RESULTS The median age was 50 years, and the follow-up duration was 31 months. The annual rate for the HBsAg seroclearance was 1.8%. In multivariable analysis, the probability of HBsAg seroclearance was positively associated with old age (p = 0.046), with a sustained inactive phase rather than the occurrence of HBeAg-negative hepatitis (p = 0.041), and with an initial HBV DNA level <2,000 IU/ml (p = 0.001).
CONCLUSION The annual rate for the HBsAg seroclearance in HBeAg-negative chronic hepatitis B patients was 1.8%. Old age, sustained inactive phase, and low levels of HBV DNA were independent predictors of HBsAg seroclearance.
PubMed IF 3.4 소화기내과
1182011

제1저자 조은주 · 교신저자 이효석

, , , , , , ,
Relative etiological role of prior hepatitis B virus infection and nonalcoholic fatty liver disease in the development of non-B non-C hepatocellular carcinoma in a hepatitis B-endemic area.
Digestion. 2011;84 Suppl 1:17-22.

Abstract
BACKGROUND AND AIMS We investigated the relative etiological role of prior hepatitis B virus (HBV) infection and nonalcoholic fatty liver disease (NAFLD) in the development of non-B non-C, non-alcohol or specific cause-related hepatocellular carcinoma (NBNC-NA-NS HCC) in an HBV-endemic area of Korea.
METHODS A total of 329 patients with NBNC-NA-NS HCC were enrolled in this study. Prior HBV infection was defined as the presence of isolated IgG hepatitis B core antibody (anti-HBc), and NAFLD was diagnosed by the findings from the imaging in the absence of a history of excessive alcohol consumption.
RESULTS Prior HBV infection was the most common cause of underlying liver disease (76.6%). Only 8.2% of the patients had NAFLD as the only risk factor and the same proportion of patients had evidence of both prior HBV infection and NAFLD. Patients without definitive causes accounted for 7.0% of the cases. During the past 10 years, the relative proportion of isolated IgG anti-HBc-positive HCC decreased significantly from 86.6% in 2001-2005 to 67.4% in 2006-2010 (p < 0.0001) and that of NAFLD-related HCC increased from 3.8% to 12.2% in the same period, respectively (p = 0.008). The mean age of NAFLD-related HCC patients (67.3 years) was significantly older than that of HCC patients related to prior HBV infection (61.2 years, p < 0.001).
CONCLUSIONS NAFLD-related HCC increased significantly while HCC related to prior HBV infection decreased during the past 10 years in an HBV-endemic area of Korea; however, the relative etiological role of prior HBV infection was still greater than that of NAFLD in the development of NBNC-NA-NS HCC.
PubMed IF 3.4 소화기내과

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